Area of research
Molecular Biology · Cardiology and Cardiovascular Medicine
Research interest
Research interests include RNA and protein synthesis mechanisms, RNA modifications and cancer, RNA Research and Splicing, and DNA and Nucleic Acid Chemistry.
Scaffold-enabled high-resolution cryo-EM structure determination of RNA
A 36-base hairpin within lncRNA DRAIC, which is modulated by alternative splicing, interacts with the IKKα coiled-coil domain and inhibits NF-κB and tumor cell phenotypes
Steering research on mRNA splicing in cancer towards clinical translation
Pervasive downstream RNA hairpins dynamically dictate start-codon selection
Direct detection of RNA modifications and structure using single-molecule nanopore sequencing
Discovery of a large-scale, cell-state-responsive allosteric switch in the 7SK RNA using DANCE-MaP
SHAPE-enabled fragment-based ligand discovery for RNA
Distinct MUNC lncRNA structural domains regulate transcription of different promyogenic factors
Subsite Ligand Recognition and Cooperativity in the TPP Riboswitch: Implications for Fragment-Linking in RNA Ligand Discovery
Principles for targeting RNA with drug-like small molecules
mRNA structure determines specificity of a polyQ-driven phase separation
Functional classification of long non-coding RNAs by k-mer content
RNA-Puzzles Round III: 3D RNA structure prediction of five riboswitches and one ribozyme
RNA motif discovery by SHAPE and mutational profiling (SHAPE-MaP)
<i>RNA-Puzzles</i> : A CASP-like evaluation of RNA three-dimensional structure prediction
In-Cell Discovery of Functional RNA Tertiary Structures
RNA Structure and Dynamics In Vivo
RNA Structure and Dynamics In Vivo
High-Throughput RNA Structure Analysis
CAREER: Nucleic Acid Mutation Detection by 2'-Amine Modification