Area of research
Biomedical Engineering · Molecular Biology
Research interest
Research topics from publications: In situ synthesis of NIR-light emitting carbon dots derived from spinach for bio-imaging applications; Multifunctional MnO2/Ag3SbS3 Nanotheranostic Agent for Single-Laser-Triggered Tumor Synergistic Therapy in the NIR-II Biowindow; Ultrasmall endogenous biopolymer nanoparticles for magnetic resonance/photoacoustic dual-modal imaging-guided photothermal therapy; Photoacoustic-imaging-guided therapy of functionalized melanin nanoparticles: combination of photothermal ablation and gene therapy against laryngeal squamous cell carcinoma; A simple POM clusters for in vivo NIR-II photoacoustic imaging-guided NIR-II photothermal therapy; Self-assembled copper chlorogenic acid nanoparticles: Inducing pyroptosis and cuproptosis to activate antitumor immunity; Hollow Manganese-Doped Calcium Phosphate Nanoparticles Treated with Melanin Nanoparticles and Thalidomide for Photothermal and Anti-angiogenic Cancer Therapy; IR820 functionalized melanin nanoplates for dual-modal imaging and photothermal tumor eradication; Design of ZIF-based hybrid nanoparticles with hyaluronic acid-augmented ROS behavior for dual-modality PA/NIR-II FL imaging; PVP-coated Sb2Se3 nanorods as nanotheranostic agents for photoacoustic imaging and photothermal therapy in NIR-I bio-windows. Representative work: Near infrared (NIR)-light emitting fluorescent probes have attracted extensive research attention in the bioimaging field due to their deep tissue penetration, minimal auto-fluorescence and lower emission light damage to bio-tissues. Herein, we designed and prepared NIR-light emitting CDs (R-CDs) from spinach by a one-step solvothermal method. The R-CDs exhibited good water solubility, a maximum fluorescence emission peak at 680 nm, a high quantum yield of 15.34%, remarkable photo-stability and resistance to metal ions in a body-simulating environment, excellent compatibility, negligible toxicity, and superior labelling capability in vitro and in vivo. These findings significantly highlight Regulating the level of reactive oxygen species (ROS) in a tumor is an efficient and innovative anticancer strategy. However, the therapeutic efficacy of ROS-based therapies, such as chemodynamic therapy (CDT) and photodynamic therapy (PDT), offers finite outcomes due to the oxygen dependence and limited concentration of hydrogen peroxide (H2O2) and overexpression of glut
Self-assembled copper chlorogenic acid nanoparticles: Inducing pyroptosis and cuproptosis to activate antitumor immunity
pH-driven butterfly effect for cascade-amplified tumor therapy based on thalidomide coordinated Fe-HMME nanoplatform
Multifunctional MnO<sub>2</sub>/Ag<sub>3</sub>SbS<sub>3</sub> Nanotheranostic Agent for Single-Laser-Triggered Tumor Synergistic Therapy in the NIR-II Biowindow
Hollow Manganese-Doped Calcium Phosphate Nanoparticles Treated with Melanin Nanoparticles and Thalidomide for Photothermal and Anti-angiogenic Cancer Therapy
Design of ZIF-based hybrid nanoparticles with hyaluronic acid-augmented ROS behavior for dual-modality PA/NIR-II FL imaging
A simple POM clusters for in vivo NIR-II photoacoustic imaging-guided NIR-II photothermal therapy
IR820 functionalized melanin nanoplates for dual-modal imaging and photothermal tumor eradication
PVP-coated Sb<sub>2</sub>Se<sub>3</sub> nanorods as nanotheranostic agents for photoacoustic imaging and photothermal therapy in NIR-I bio-windows
Synthesis, fluorescence property and cell imaging of a perylene diimide-based NIR fluorescent probe for hypochlorite with dual-emission fluorescence responses
Photoacoustic-imaging-guided therapy of functionalized melanin nanoparticles: combination of photothermal ablation and gene therapy against laryngeal squamous cell carcinoma
Ultrasmall endogenous biopolymer nanoparticles for magnetic resonance/photoacoustic dual-modal imaging-guided photothermal therapy
In situ synthesis of NIR-light emitting carbon dots derived from spinach for bio-imaging applications