Area of research
Genetics · Molecular Biology
Research interest
Research interests include Genetic and Kidney Cyst Diseases, Renal and related cancers, Hedgehog Signaling Pathway Studies, and Genetic Syndromes and Imprinting.
Resident macrophage subpopulations occupy distinct microenvironments in the kidney
Variable phenotypes and penetrance between and within different zebrafish ciliary transition zone mutants
A kidney resident macrophage subset is a candidate biomarker for renal cystic disease in preclinical models
A ciliopathy complex builds distal appendages to initiate ciliogenesis
Evolutionarily conserved genetic interactions between <i>nphp-4</i> and <i>bbs-5</i> mutations exacerbate ciliopathy phenotypes
A mouse model of BBS identifies developmental and homeostatic effects of BBS5 mutation and identifies novel pituitary abnormalities
Interferon Regulatory Factor‐5 in Resident Macrophage Promotes Polycystic Kidney Disease
BBSome Component BBS5 Is Required for Cone Photoreceptor Protein Trafficking and Outer Segment Maintenance
Human transcription factors responsive to initial reprogramming predominantly undergo legitimate reprogramming during fibroblast conversion to iPSCs
Resident Macrophages in Cystic Kidney Disease
Single-Cell RNA Sequencing Identifies Candidate Renal Resident Macrophage Gene Expression Signatures across Species
Resident macrophages reprogram toward a developmental state after acute kidney injury
Tissue-Resident Macrophages Promote Renal Cystic Disease
Increased flux through the mevalonate pathway mediates fibrotic repair without injury
Urinary T cells correlate with rate of renal function loss in autosomal dominant polycystic kidney disease
Heterozygous <i>Pkhd1</i><sup>C642*</sup> mice develop cystic liver disease and proximal tubule ectasia that mimics radiographic signs of medullary sponge kidney
Intravital visualization of the primary cilium, tubule flow, and innate immune cells in the kidney utilizing an abdominal window imaging approach
Role for intraflagellar transport in building a functional transition zone
Primary cilia disruption differentially affects the infiltrating and resident macrophage compartment in the liver
Mks6 mutations reveal tissue‐ and cell type‐specific roles for the cilia transition zone
Truncating <i>PKHD1</i> and <i>PKD2</i> mutations alter energy metabolism
Inflammation and Fibrosis in Polycystic Kidney Disease
The Tumor-Associated Glycosyltransferase ST6Gal-I Regulates Stem Cell Transcription Factors and Confers a Cancer Stem Cell Phenotype
Coiled-coil domain containing 42 ( Ccdc 42) is necessary for proper sperm development and male fertility in the mouse
Mutation of Growth Arrest Specific 8 Reveals a Role in Motile Cilia Function and Human Disease
A Screen for Modifiers of Cilia Phenotypes Reveals Novel MKS Alleles and Uncovers a Specific Genetic Interaction between osm-3 and nphp-4
KIAA0556 is a novel ciliary basal body component mutated in Joubert syndrome
Heterotrimeric Kinesin-2 (KIF3) Mediates Transition Zone and Axoneme Formation of Mouse Photoreceptors
SnapShot: Sensing and Signaling by Cilia
Genetic and Informatic Analyses Implicate Kif12 as a Candidate Gene within the Mpkd2 Locus That Modulates Renal Cystic Disease Severity in the Cys1cpk Mouse
CDKN1A (p21) regulation of cyst growth
CDKN1A (p21) regulation of cyst growth
Defining the ciliary proteomes in vivo
Defining the ciliary proteomes in vivo
Mechanisms of ciliopathy associated structural birth defects
Mechanisms of ciliopathy associated structural birth defects
Injury Response Mediated Pathogenesis in Renal Ciliopathies
Injury Response Mediated Pathogenesis in Renal Ciliopathies
Injury Response Mediated Pathogenesis in Renal Ciliopathies
Injury Response Mediated Pathogenesis in Renal Ciliopathies
Application of Progenitor Niche Signals to Ex Vivo Nephrogenesis
Application of Progenitor Niche Signals to Ex Vivo Nephrogenesis
Application of Progenitor Niche Signals to Ex Vivo Nephrogenesis
Application of Progenitor Niche Signals to Ex Vivo Nephrogenesis
Application of Progenitor Niche Signals to Ex Vivo Nephrogenesis
UAB Pilot Center for Precision Animal Modeling (C-PAM)
UAB Pilot Center for Precision Animal Modeling (C-PAM)
UAB Pilot Center for Precision Animal Modeling (C-PAM)
UAB Center for Precision Animal Modeling (CPAM)
UAB Childhood Cystic Kidney Disease Core Center (UAB-CCKDCC)
UAB Childhood Cystic Kidney Disease Center (UAB-CCKDC)
UAB Childhood Cystic Kidney Disease Core Center (UAB-CCKDCC)
UAB Pilot Center for Precision Animal Modeling (C-PAM)
Intravital analysis of cilia function during injury in the kidney
Intravital analysis of cilia function during injury in the kidney