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Leda Bassit

Children's Healthcare of Atlanta · US
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Area of research
Infectious Diseases · Hepatology
Research interest
Research interests include Hepatitis C virus research, Hepatitis B Virus Studies, HIV/AIDS drug development and treatment, and SARS-CoV-2 and COVID-19 Research.
h-index
30
citations
3,103
works
150
NIH funding
primary concept
email

Recent publications

The Discovery and Preclinical Profile of ALG-000184, a Prodrug of the Potent Hepatitis B Virus Capsid Assembly Modulator ALG-001075
Journal of Medicinal Chemistry 2024cited by 24position: middledoi
Deep mutational scanning identifies SARS-CoV-2 Nucleocapsid escape mutations of currently available rapid antigen tests
Cell 2022cited by 55position: middledoi
The Mechanism of Action of Hepatitis B Virus Capsid Assembly Modulators Can Be Predicted from Binding to Early Assembly Intermediates
Journal of Medicinal Chemistry 2022cited by 34position: middledoi
Baicalein and Baicalin Inhibit SARS-CoV-2 RNA-Dependent-RNA Polymerase
Microorganisms 2021cited by 132position: middledoi
Multidisciplinary assessment of the Abbott BinaxNOW SARS-CoV-2 point-of-care antigen test in the context of emerging viral variants and self-administration
Scientific Reports 2021cited by 77position: middledoi
Comparison of anti-SARS-CoV-2 activity and intracellular metabolism of remdesivir and its parent nucleoside
Current Research in Pharmacology and Drug Discovery 2021cited by 32position: middledoi
Single-Amplicon Multiplex Real-Time Reverse Transcription-PCR with Tiled Probes To Detect SARS-CoV-2 <i>spike</i> Mutations Associated with Variants of Concern
Journal of Clinical Microbiology 2021cited by 30position: middledoi
Encephalopathy and Encephalitis Associated with Cerebrospinal Fluid Cytokine Alterations and Coronavirus Disease, Atlanta, Georgia, USA, 2020
Emerging infectious diseases 2020cited by 179position: middledoi
Repurposing Nucleoside Analogs for Human Coronaviruses
Antimicrobial Agents and Chemotherapy 2020cited by 66position: middledoi
Antibody Profiles According to Mild or Severe SARS-CoV-2 Infection, Atlanta, Georgia, USA, 2020
Emerging infectious diseases 2020cited by 46position: middledoi
Potent in vitro activity of β-D-4ʹ-chloromethyl-2ʹ-deoxy-2ʹ-fluorocytidine against Nipah virus
Antiviral Research 2020cited by 27position: middledoi
Novel Hepatitis B Virus Capsid Assembly Modulator Induces Potent Antiviral Responses <i>In Vitro</i> and in Humanized Mice
Antimicrobial Agents and Chemotherapy 2019cited by 45position: middledoi
Nucleoside Analogs with Selective Antiviral Activity against Dengue Fever and Japanese Encephalitis Viruses
Antimicrobial Agents and Chemotherapy 2019cited by 38position: middledoi
Discovery of a Series of 2′-α-Fluoro,2′-β-bromo-ribonucleosides and Their Phosphoramidate Prodrugs as Potent Pan-Genotypic Inhibitors of Hepatitis C Virus
Journal of Medicinal Chemistry 2019cited by 22position: middledoi
Towards <scp>HBV</scp> curative therapies
Liver International 2018cited by 77position: middledoi
Zika in the Americas, year 2: What have we learned? What gaps remain? A report from the Global Virus Network
Antiviral Research 2017cited by 132position: middledoi
Synthesis of sulfamoylbenzamide derivatives as HBV capsid assembly effector
European Journal of Medicinal Chemistry 2017cited by 46position: middledoi
2′-Chloro,2′-fluoro Ribonucleotide Prodrugs with Potent Pan-genotypic Activity against Hepatitis C Virus Replication in Culture
Journal of Medicinal Chemistry 2017cited by 29position: middledoi
Toward Elimination of Hepatitis B Virus Using Novel Drugs, Approaches, and Combined Modalities
Clinics in Liver Disease 2016cited by 27position: middledoi
β-<scp>d</scp>-2′-<i>C</i>-Methyl-2,6-diaminopurine Ribonucleoside Phosphoramidates are Potent and Selective Inhibitors of Hepatitis C Virus (HCV) and Are Bioconverted Intracellularly to Bioactive 2,6-Diaminopurine and Guanosine 5′-Triphosphate Forms
Journal of Medicinal Chemistry 2015cited by 32position: middledoi
Suppression of hepatitis B virus DNA accumulation in chronically infected cells using a bacterial CRISPR/Cas RNA-guided DNA endonuclease
Virology 2014cited by 236position: middledoi
Approaches to hepatitis C treatment and cure using NS5A inhibitors
Infection and Drug Resistance 2014cited by 57position: middledoi
Cellular Pharmacology and Potency of HIV-1 Nucleoside Analogs in Primary Human Macrophages
Antimicrobial Agents and Chemotherapy 2012cited by 35position: middledoi

Grants

No grants ingested yet.

Frequent collaborators

Raymond F. Schinazi · Emory University19 papers (2012–2022)Franck Amblard · Emory University12 papers (2014–2022)Maryam Ehteshami · Emory University6 papers (2014–2019)Olivia Ollinger Russell · Centers for Disease Control and Prevention6 papers (2017–2020)Sijia Tao · Emory University5 papers (2015–2021)Tamara R. McBrayer · Emory University5 papers (2015–2021)Keivan Zandi · Emory University4 papers (2019–2021)Tuğba Öztürk · Balıkesir University4 papers (2017–2020)Bryan D. Cox · San Mateo County Health System4 papers (2017–2022)Longhu Zhou · Emory University4 papers (2015–2019)Ozkan Sari · Emory University4 papers (2017–2019)Kiran Verma · Indraprastha Apollo Hospitals4 papers (2019–2021)Sébastien Bouclé · Emory University3 papers (2016–2019)Steven J. Coats · Children's Healthcare of Atlanta3 papers (2015–2019)James J. Kohler · Emory University3 papers (2014–2021)Baek Kim · Children's Healthcare of Atlanta3 papers (2020–2021) · 3 papers (2015–2019)Bo Liang · Broad Institute2 papers (2020–2021)Mervi Detorio · Centers for Disease Control and Prevention2 papers (2012–2015)Mahesh Kasthuri · Emory University2 papers (2019–2020)
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