Area of research
Immunology · Virology
Research interest
Research interests include HIV Research and Treatment, Immune Cell Function and Interaction, T-cell and B-cell Immunology, and Immunotherapy and Immune Responses.
Vaccination with an mRNA-encoded membrane-bound HIV envelope trimer induces neutralizing antibodies in animal models
Human immunoglobulin gene allelic variation impacts germline-targeting vaccine priming
mRNA-LNP prime boost evolves precursors toward VRC01-like broadly neutralizing antibodies in preclinical humanized mouse models
Vaccination induces HIV broadly neutralizing antibody precursors in humans
Combined PET and whole-tissue imaging of lymphatic-targeting vaccines in non-human primates
Multifaceted Effects of Antigen Valency on B Cell Response Composition and Differentiation In Vivo
Engineered immunogen binding to alum adjuvant enhances humoral immunity
B cells expressing authentic naive human VRC01-class BCRs can be recruited to germinal centers and affinity mature in multiple independent mouse models
Targeting HIV Env immunogens to B cell follicles in nonhuman primates through immune complex or protein nanoparticle formulations
Author Correction: A Engineered immunogen binding to alum adjuvant enhances humoral immunity
Slow Delivery Immunization Enhances HIV Neutralizing Antibody and Germinal Center Responses via Modulation of Immunodominance
Enhancing humoral immunity via sustained-release implantable microneedle patch vaccination
Rapid and Focused Maturation of a VRC01-Class HIV Broadly Neutralizing Antibody Lineage Involves Both Binding and Accommodation of the N276-Glycan
Immunogenicity of RNA Replicons Encoding HIV Env Immunogens Designed for Self-Assembly into Nanoparticles
Innate immune recognition of glycans targets HIV nanoparticle immunogens to germinal centers
The human naive B cell repertoire contains distinct subclasses for a germline-targeting HIV-1 vaccine immunogen
Enhancing Humoral Responses Against HIV Envelope Trimers via Nanoparticle Delivery with Stabilized Synthetic Liposomes
Precursor Frequency and Affinity Determine B Cell Competitive Fitness in Germinal Centers, Tested with Germline-Targeting HIV Vaccine Immunogens
HIV Vaccine Design to Target Germline Precursors of Glycan-Dependent Broadly Neutralizing Antibodies
Holes in the Glycan Shield of the Native HIV Envelope Are a Target of Trimer-Elicited Neutralizing Antibodies
Induction of HIV Neutralizing Antibody Lineages in Mice with Diverse Precursor Repertoires
Glycan clustering stabilizes the mannose patch of HIV-1 and preserves vulnerability to broadly neutralizing antibodies
Promiscuous Glycan Site Recognition by Antibodies to the High-Mannose Patch of gp120 Broadens Neutralization of HIV