Area of research
Signal Processing · Electrical and Electronic Engineering
Research interest
Research topics from publications: Gene expression profile of dermal mesenchymal stem cells from patients with psoriasis; mRNA and protein expression of the angiogenesis-related genesEDIL3, AMOTandECM1in mesenchymal stem cells in psoriatic dermis. Representative work: BACKGROUND: Mesenchymal stem cells (MSCs) are likely involved in pathological processes of immune-related diseases, including psoriasis because of their immunoregulatory and pro-angiogenic effects, and the vascular proliferation, angiectasis and perivascular lymphocyte infiltration are known to be predominantly responsible for the pathological alterations in psoriasis. OBJECTIVE: This study aimed to investigate the gene expression profile of dermal MSCs from patients with psoriasis. METHODS: We isolated and expanded dermal MSCs from psoriatic patients and normal controls by using the attachment assay and conducted mRNA expression profile and gene ontology analyses using microarray. RESULTS: BACKGROUND: Dermal microvasculature expansion and angiogenesis are prominent in psoriasis. Our previous microarray study showed that the angiogenesis-related genes EDIL3 (epidermal growth factor-like repeats and discoidin I-like domains 3), AMOT (angiomotin) and ECM1 (extracellular matrix protein 1), had high expression levels in dermal mesenchymal stem cells (DMSCs) from psoriatic skin lesions. AIM: To investigate the mRNA and protein expressions of EDIL3, AMOT and ECM1 in DMSCs derived from psoriatic skin in order to better determine the molecular mechanisms of angiogenesis in the skin. METHODS: DMSCs from 12 patients with psoriasis and 14 healthy controls (HCs) were cultured to passage 3,