Area of research
Molecular Biology · Physiology
Research interest
Research interests include Adenosine and Purinergic Signaling, Receptor Mechanisms and Signaling, Computational Drug Discovery Methods, and Pharmacological Receptor Mechanisms and Effects.
Pharmacological suppression of the OTUD4/CD73 proteolytic axis revives antitumor immunity against immune-suppressive breast cancers
Systematic discovery of mutation-directed neo-protein-protein interactions in cancer
Surfaceome profiling to reveal unique therapeutic vulnerabilities in transcriptional subtypes of small cell lung cancer (SCLC).
An expanded universe of cancer targets
YAP1 Expression in SCLC Defines a Distinct Subtype With T-cell–Inflamed Phenotype
Hypomorph mutation-directed small-molecule protein-protein interaction inducers to restore mutant SMAD4-suppressed TGF-β signaling
High expression of MKK3 is associated with worse clinical outcomes in African American breast cancer patients
In vivo screening identifies GATAD2B as a metastasis driver in KRAS-driven lung cancer
The OncoPPi network of cancer-focused protein–protein interactions to inform biological insights and therapeutic strategies
The OncoPPi Portal: an integrative resource to explore and prioritize protein–protein interactions for cancer target discovery
OncoPPi-informed discovery of mitogen-activated protein kinase kinase 3 as a novel binding partner of c-Myc
AKT1, LKB1, and YAP1 Revealed as MYC Interactors with NanoLuc-Based Protein-Fragment Complementation Assay
Enabling systematic interrogation of protein–protein interactions in live cells with a versatile ultra-high-throughput biosensor platform
Targeting protein–protein interactions as an anticancer strategy