Area of research
Molecular Biology · Genetics
Research interest
Research interests include Biology, Cell biology, Stem cell, Wnt signaling pathway, Transcription factor, and Enhancer.
Niche-driven phenotypic plasticity and cis-regulatory dynamics of a revised model for intestinal secretory differentiation
Short-term post-fast refeeding enhances intestinal stemness via polyamines
Graded BMP signaling within intestinal crypt architecture directs self-organization of the Wnt-secreting stem cell niche
Role of PDGFRA+ cells and a CD55+ PDGFRALo fraction in the gastric mesenchymal niche
SATB2 preserves colon stem cell identity and mediates ileum-colon conversion via enhancer remodeling
Creb5 establishes the competence for Prg4 expression in articular cartilage
Distinct Mesenchymal Cell Populations Generate the Essential Intestinal BMP Signaling Gradient
Ascl2-Dependent Cell Dedifferentiation Drives Regeneration of Ablated Intestinal Stem Cells
Creb5 establishes the competence for <i>Prg4</i> expression in articular cartilage
Enhancer signatures stratify and predict outcomes of non-functional pancreatic neuroendocrine tumors
Extensive Recovery of Embryonic Enhancer and Gene Memory Stored in Hypomethylated Enhancer DNA
Publisher Correction: Enhancer signatures stratify and predict outcomes of non-functional pancreatic neuroendocrine tumors
Challenges and emerging directions in single-cell analysis
Dynamic Reorganization of Chromatin Accessibility Signatures during Dedifferentiation of Secretory Precursors into Lgr5+ Intestinal Stem Cells
ARID1A loss impairs enhancer-mediated gene regulation and drives colon cancer in mice
Acquired Tissue-Specific Promoter Bivalency Is a Basis for PRC2 Necessity in Adult Cells
Single-Cell Transcript Profiles Reveal Multilineage Priming in Early Progenitors Derived from Lgr5+ Intestinal Stem Cells
Sox2 Suppresses Gastric Tumorigenesis in Mice
The androgen receptor cistrome is extensively reprogrammed in human prostate tumorigenesis
The use of murine‐derived fundic organoids in studies of gastric physiology
Dissecting Engineered Cell Types and Enhancing Cell Fate Conversion via CellNet
Broadly permissive intestinal chromatin underlies lateral inhibition and cell plasticity
Wnt Secretion from Epithelial Cells and Subepithelial Myofibroblasts Is Not Required in the Mouse Intestinal Stem Cell Niche In Vivo
Gastrointestinal Adenocarcinomas of the Esophagus, Stomach, and Colon Exhibit Distinct Patterns of Genome Instability and Oncogenesis
Intact function of Lgr5 receptor-expressing intestinal stem cells in the absence of Paneth cells
Targeted Disruption of the BCL9/β-Catenin Complex Inhibits Oncogenic Wnt Signaling