Area of research
Cellular and Molecular Neuroscience · Psychiatry and Mental health
Research interest
Research interests include Neurotransmitter Receptor Influence on Behavior, Schizophrenia research and treatment, Neuroscience and Neuropharmacology Research, and Receptor Mechanisms and Signaling.
Why Is Clozapine Uniquely Effective in Treatment-Resistant Schizophrenia? A Review and Proposal
Synaptic Terminal Density Early in the Course of Schizophrenia: An In Vivo UCB-J Positron Emission Tomographic Imaging Study of SV2A
A Method for Tapering Antipsychotic Treatment That May Minimize the Risk of Relapse
The relationship between synaptic density marker SV2A, glutamate and N-acetyl aspartate levels in healthy volunteers and schizophrenia: a multimodal PET and magnetic resonance spectroscopy brain imaging study
Synaptic density marker SV2A is reduced in schizophrenia patients and unaffected by antipsychotics in rats
Reproducing the dopamine pathophysiology of schizophrenia and approaches to ameliorate it: a translational imaging study with ketamine
Comparative effects of 18 antipsychotics on metabolic function in patients with schizophrenia, predictors of metabolic dysregulation, and association with psychopathology: a systematic review and network meta-analysis
Antipsychotics: Mechanisms underlying clinical response and side-effects and novel treatment approaches based on pathophysiology
The Effects of Antipsychotic Treatment on Presynaptic Dopamine Synthesis Capacity in First-Episode Psychosis: A Positron Emission Tomography Study
Regulation of dopaminergic function: an [18F]-DOPA PET apomorphine challenge study in humans.
Should psychiatrists be more cautious about the long-term prophylactic use of antipsychotics?
Loss of extra-striatal phosphodiesterase 10A expression in early premanifest Huntington's disease gene carriers
Loss of phosphodiesterase 10A expression is associated with progression and severity in Parkinson’s disease
Altered PDE10A expression detectable early before symptomatic onset in Huntington’s disease
Microglial activation in the rat brain following chronic antipsychotic treatment at clinically relevant doses
Phosphodiesterase 10A PET Radioligand Development Program: From Pig to Human
Contrasting Effects of Haloperidol and Lithium on Rodent Brain Structure: A Magnetic Resonance Imaging Study with Postmortem Confirmation