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Stuart C. Sealfon

Icahn School of Medicine at Mount Sinai · US
Area of research
Molecular Biology · Reproductive Medicine
Research interest
Research interests include Receptor Mechanisms and Signaling, Single-cell and spatial transcriptomics, Hypothalamic control of reproductive hormones, and interferon and immune responses.
h-index
72
citations
20,696
works
346
NIH funding
primary concept
email

Recent publications

Heterogeneous Macrophage Activation in Acute Skeletal Muscle Sterile Injury and mdx5cv Model of Muscular Dystrophy
International Journal of Molecular Sciences 2025cited by 5position: middledoi
Temporal dynamics of the multi-omic response to endurance exercise training
Nature 2024cited by 225position: middledoi
Physiological Adaptations to Progressive Endurance Exercise Training in Adult and Aged Rats: Insights from the Molecular Transducers of Physical Activity Consortium (MoTrPAC)
Function 2024cited by 28position: middledoi
Molecular Transducers of Physical Activity Consortium (MoTrPAC): human studies design and protocol
Journal of Applied Physiology 2024cited by 19position: middledoi
Mapping disease regulatory circuits at cell-type resolution from single-cell multiomics data
Nature Computational Science 2023cited by 25position: lastdoi
Single nucleus transcriptome and chromatin accessibility of postmortem human pituitaries reveal diverse stem cell regulatory mechanisms
Cell Reports 2022cited by 69position: middledoi
Skeletal muscle transcriptome response to a bout of endurance exercise in physically active and sedentary older adults
American Journal of Physiology-Endocrinology and Metabolism 2022cited by 40position: middledoi
Diverse effector and regulatory functions of fibro/adipogenic progenitors during skeletal muscle fibrosis in muscular dystrophy
iScience 2022cited by 33position: middledoi
Pre-infection antiviral innate immunity contributes to sex differences in SARS-CoV-2 infection
Cell Systems 2022cited by 21position: middledoi
Single nucleus multi-omics regulatory landscape of the murine pituitary
Nature Communications 2021cited by 74position: lastdoi
TGFBR3L is an inhibin B co-receptor that regulates female fertility
Science Advances 2021cited by 37position: middledoi
Endocrinology of a Single Cell: Tools and Insights
Elsevier eBooks 2021cited by 0position: lastdoi
Single-cell transcriptional profiles in human skeletal muscle
Scientific Reports 2020cited by 334position: lastdoi
Heterogeneous origins and functions of mouse skeletal muscle-resident macrophages
Proceedings of the National Academy of Sciences 2020cited by 109position: middledoi
Rehabilitative Impact of Exercise Training on Human Skeletal Muscle Transcriptional Programs in Parkinson’s Disease
Frontiers in Physiology 2020cited by 26position: middledoi
Innate Immune Response to Influenza Virus at Single-Cell Resolution in Human Epithelial Cells Revealed Paracrine Induction of Interferon Lambda 1
Journal of Virology 2019cited by 103position: middledoi
Skeletal muscle transcriptional networks linked to type I myofiber grouping in Parkinson’s disease
Journal of Applied Physiology 2019cited by 29position: middledoi
Cytogenetic, Genomic, and Functional Characterization of Pituitary Gonadotrope Cell Lines
Journal of the Endocrine Society 2019cited by 20position: lastdoi
Tellurium notebooks—An environment for reproducible dynamical modeling in systems biology
PLoS Computational Biology 2018cited by 59position: middledoi
Regulatory Architecture of the LβT2 Gonadotrope Cell Underlying the Response to Gonadotropin-Releasing Hormone
Frontiers in Endocrinology 2018cited by 31position: lastdoi
Single-cell stabilization method identifies gonadotrope transcriptional dynamics and pituitary cell type heterogeneity
Nucleic Acids Research 2018cited by 22position: lastdoi
Modeling and high-throughput experimental data uncover the mechanisms underlying Fshb gene sensitivity to gonadotropin-releasing hormone pulse frequency
Journal of Biological Chemistry 2017cited by 22position: lastdoi
RIPK3 Activates Parallel Pathways of MLKL-Driven Necroptosis and FADD-Mediated Apoptosis to Protect against Influenza A Virus
Cell Host & Microbe 2016cited by 366position: middledoi
Solving Immunology?
Trends in Immunology 2016cited by 52position: lastdoi
Cross-signaling in metabotropic glutamate 2 and serotonin 2A receptor heteromers in mammalian cells
Pflügers Archiv - European Journal of Physiology 2016cited by 33position: middledoi
Understanding multicellular function and disease with human tissue-specific networks
Nature Genetics 2015cited by 926position: middledoi
Homer1 Alternative Splicing Is Regulated by Gonadotropin-Releasing Hormone and Modulates Gonadotropin Gene Expression
Molecular and Cellular Biology 2014cited by 9position: lastdoi
Reconstruction of regulatory networks through temporal enrichment profiling and its application to H1N1 influenza viral infection
BMC Bioinformatics 2013cited by 22position: middledoi
Cytokine Response Is Determined by Duration of Receptor and Signal Transducers and Activators of Transcription 3 (STAT3) Activation
Journal of Biological Chemistry 2012cited by 166position: lastdoi
Identification of Three Residues Essential for 5-Hydroxytryptamine 2A-Metabotropic Glutamate 2 (5-HT2A·mGlu2) Receptor Heteromerization and Its Psychoactive Behavioral Function
Journal of Biological Chemistry 2012cited by 132position: middledoi

Grants

Molecular Biology and Biosynthetic Regulation of the GnRH Receptor
NSF9106877$259,0001991–1994PIRePORTER

Frequent collaborators

Frederique Ruf-Zamojski · Cedars-Sinai Medical Center12 papers (2017–2025)Venugopalan D. Nair · Icahn School of Medicine at Mount Sinai9 papers (2018–2022)Hanna Pinças · Icahn School of Medicine at Mount Sinai7 papers (2014–2022)Gregory R. Smith · Icahn School of Medicine at Mount Sinai7 papers (2018–2025)Elena Zaslavsky · Icahn School of Medicine at Mount Sinai7 papers (2013–2022)Judith L. Turgeon · University of California, Davis6 papers (2017–2022)Boris Hartmann · University of Veterinary Medicine Vienna5 papers (2013–2019) · 5 papers (2012–2019)Yongchao Ge · Columbia University5 papers (2018–2020)Daniel J. Bernard · McGill University Health Centre4 papers (2018–2022)Michel Zamojski · Columbia University4 papers (2018–2022)Lan Zhou · Hospital for Special Surgery4 papers (2020–2025)Marcas M. Bamman · University of Alabama at Birmingham3 papers (2019–2022)German Nudelman · Icahn School of Medicine at Mount Sinai3 papers (2013–2022)Kaleen M. Lavin · University of Alabama at Birmingham2 papers (2019–2020)José L. Moreno · University of California, Riverside2 papers (2012–2016)Natalia Mendelev · Icahn School of Medicine at Mount Sinai2 papers (2021–2022)Steven H. Kleinstein · Yale University2 papers (2013–2016)Chirine Toufaily · McGill University2 papers (2018–2019)Samuel T. Windham · University of Alabama at Birmingham2 papers (2019–2020)