Baojun Duan

Area of research

Molecular Biology · Radiation

Research interest

Research topics from publications: Luteolin exerts an anticancer effect on gastric cancer cells through multiple signaling pathways and regulating miRNAs; Baicalein sensitizes hepatocellular carcinoma cells to 5-FU and Epirubicin by activating apoptosis and ameliorating P-glycoprotein activity; Colorectal Cancer: An Overview; Claudin 18.2 is a potential therapeutic target for zolbetuximab in pancreatic ductal adenocarcinoma; Histone-lysine N-methyltransferase SETD7 is a potential serum biomarker for colorectal cancer patients; Clinical significance of controlling nutritional status score (CONUT) in evaluating outcome of postoperative patients with gastric cancer; Norepinephrine‐CREB1‐miR‐373 axis promotes progression of colon cancer; Multidrug Resistance in Hepatocellular Carcinoma; RNA‐Binding Motif Protein 6 is a Candidate Serum Biomarker for Pancreatic Cancer; A New Role for the Spleen. Representative work: Accumulating studies confirmed that luteolin, a common dietary flavonoid which is widely distributed in plants and has diverse beneficial biological function, including anti-oxidant, anti-inflammation and anticancer properties. However, the detail mechanisms of luteolin on GC are poorly understood. Here, we investigated the anticancer effect of luteolin in GC cells in vitro and in vivo. Luteolin reduced the cell viability in a time and dose-dependent manner. Luteolin significantly inhibited cell cycle progress, colony formation, proliferation, migration, invasion and promoted apoptosis in vitro and in vivo. Luteolin also regulated these biological effects associated regulators. Mechanically, Colorectal cancer is a multifactorial disease. It is the third most frequently diagnosed cancer, and the second most common cause of cancer-related deaths worldwide. The etiology of colorectal cancer remains unclear. Although early diagnosis can significantly improve the prognosis, colorectal cancer patients often have no typical clinical manifestations, or display only non-specific signs in the early stage, resulting in a low early diagnosis rate. Multiple treatment modalities, depending on the stage of the tumor and patient characteristics, are available. These include surgery, chemotherapy, radiotherapy, molecular targeted therapy, immunotherapy, and other programs. This chapter provides

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