Area of research
Oncology · Pulmonary and Respiratory Medicine
Research interest
I am a diagnostic and experimental anatomic and molecular pathologist at Brigham & Women’s Hospital and a Professor of Pathology at Harvard Medical School. My research has focused on developing and applying novel tissue-based biomarker assays to improve the diagnosis, classification, and treatment of human cancers. My laboratory has developed, validated, and implemented numerous novel immunostains, transcriptional profiling assays, and molecular genetic tests to capture critical biological markers applicable to a range of human tumor types.
Genomic mediators of acquired resistance to immunotherapy in metastatic melanoma
Society for Immunotherapy of Cancer: updates and best practices for multiplex immunohistochemistry (IHC) and immunofluorescence (IF) image analysis and data sharing
CellLENS enables cross-domain information fusion for enhanced cell population delineation in single-cell spatial omics data
CRATER tumor niches facilitate CD8+ T cell engagement and correspond with immunotherapy success
A cellular and spatial atlas of TP53-associated tissue remodeling defines a multicellular tumor ecosystem in lung adenocarcinoma
SlideCNA: spatial copy number alteration detection from Slide-seq-like spatial transcriptomics data
Author Correction: A multi-modal single-cell and spatial expression map of metastatic breast cancer biopsies across clinicopathological features
A multi-modal single-cell and spatial expression map of metastatic breast cancer biopsies across clinicopathological features
Intrapatient variation in PD-L1 expression and tumor mutational burden and the impact on outcomes to immune checkpoint inhibitor therapy in patients with non-small-cell lung cancer
A multidimensional analysis reveals distinct immune phenotypes and the composition of immune aggregates in pediatric acute myeloid leukemia
Association of Baseline Tumor-Specific Neoantigens and CD8<sup>+</sup> T-Cell Infiltration With Immune-Related Adverse Events Secondary to Immune Checkpoint Inhibitors
Preexisting tumor-resident T cells with cytotoxic potential associate with response to neoadjuvant anti–PD-1 in head and neck cancer
Mechanisms of response and resistance to combined decitabine and ipilimumab for advanced myeloid disease
Impact of Aneuploidy and Chromosome 9p Loss on Tumor Immune Microenvironment and Immune Checkpoint Inhibitor Efficacy in NSCLC
Spatially aware deep learning reveals tumor heterogeneity patterns that encode distinct kidney cancer states
Inference of single cell profiles from histology stains with the Single Cell omics from Histology Analysis Framework (SCHAF)
Multicenter randomized controlled trial of neoadjuvant chemoradiotherapy alone or in combination with pembrolizumab in patients with resectable or borderline resectable pancreatic adenocarcinoma
Intertumoral lineage diversity and immunosuppressive transcriptional programs in well-differentiated gastroenteropancreatic neuroendocrine tumors
A cellular and spatial atlas of <i>TP53</i> -associated tissue remodeling in lung adenocarcinoma
Association of High Tumor Mutation Burden in Non–Small Cell Lung Cancers With Increased Immune Infiltration and Improved Clinical Outcomes of PD-L1 Blockade Across PD-L1 Expression Levels
Landscape of helper and regulatory antitumour CD4+ T cells in melanoma
Genomic profiling for clinical decision making in lymphoid neoplasms
Dissecting the clinicopathologic, genomic, and immunophenotypic correlates of KRASG12D-mutated non-small-cell lung cancer
Expansion, persistence, and efficacy of donor memory-like NK cells infused for posttransplant relapse
DOAJ (DOAJ: Directory of Open Access Journals) 2022cited by 99position: middle
Clonal KEAP1 mutations with loss of heterozygosity share reduced immunotherapy efficacy and low immune cell infiltration in lung adenocarcinoma
Reversal of viral and epigenetic HLA class I repression in Merkel cell carcinoma
Abstract PD6-03: Spatio-molecular dissection of the breast cancer metastatic microenvironment
Personal neoantigen vaccines induce persistent memory T cell responses and epitope spreading in patients with melanoma
Expansion sequencing: Spatially precise in situ transcriptomics in intact biological systems
Therapeutically Increasing MHC-I Expression Potentiates Immune Checkpoint Blockade