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Flemming R. Cassee

Utrecht University · NL
Area of research
Health, Toxicology and Mutagenesis · Materials Chemistry
Research interest
Research interests include Particulates, Inhalation, Medicine, Environmental science, Inhalation exposure, and Air pollution.
h-index
citations
8,129
works
83
NIH funding
primary concept
email

Recent publications

Copper-enriched automotive brake wear particles perturb human alveolar cellular homeostasis
Particle and Fibre Toxicology 2025cited by 15position: middledoi
Safe and sustainable by design-compliant LDPE food packaging embedding multicomponent nanomaterials for food protection
Environmental Science Nano 2025cited by 1position: middledoi
First-in-human controlled inhalation of thin graphene oxide nanosheets to study acute cardiorespiratory responses
Nature Nanotechnology 2024cited by 74position: middledoi
Roadmap towards safe and sustainable advanced and innovative materials. (Outlook for 2024-2030)
Computational and Structural Biotechnology Journal 2024cited by 49position: firstdoi
Improving the dichloro-dihydro-fluorescein (DCFH) assay for the assessment of intracellular reactive oxygen species formation by nanomaterials
NanoImpact 2024cited by 36position: middledoi
Micro- and nanoplastics concepts for particle and fibre toxicologists
Particle and Fibre Toxicology 2024cited by 27position: middledoi
Expanded PAH analysis of household air pollution in a rural region of China with high lung cancer incidence
Environmental Pollution 2024cited by 13position: middledoi
Biodistribution of cerium dioxide and titanium dioxide nanomaterials in rats after single and repeated inhalation exposures
Particle and Fibre Toxicology 2024cited by 11position: lastdoi
The State of the Art and Challenges of In Vitro Methods for Human Hazard Assessment of Nanomaterials in the Context of Safe-by-Design
Nanomaterials 2023cited by 42position: middledoi
Placental-fetal distribution of carbon particles in a pregnant rabbit model after repeated exposure to diluted diesel engine exhaust
Particle and Fibre Toxicology 2023cited by 13position: lastdoi
97 Transferability and Reproducibility of Exposed Air-Liquid Interface co-Culture Lung Models
Annals of Work Exposures and Health 2023cited by 2position: middledoi
An inter-laboratory effort to harmonize the cell-delivered in vitro dose of aerosolized materials
NanoImpact 2022cited by 33position: middledoi
The Road to Achieving the European Commission's Chemicals Strategy for Nanomaterial Sustainability—A PATROLS Perspective on New Approach Methodologies
Small 2022cited by 31position: lastdoi
Relationship Between Particle Properties and Immunotoxicological Effects of Environmentally-Sourced Microplastics
Frontiers in Water 2022cited by 17position: middledoi
Road tunnel-derived coarse, fine and ultrafine particulate matter: physical and chemical characterization and pro-inflammatory responses in human bronchial epithelial cells
Particle and Fibre Toxicology 2022cited by 15position: middledoi
Unveiling the Toxicity of Fine and Nano-Sized Airborne Particles Generated from Industrial Thermal Spraying Processes in Human Alveolar Epithelial Cells
International Journal of Molecular Sciences 2022cited by 10position: middledoi
Global Air Quality and COVID-19 Pandemic: Do We Breathe Cleaner Air?
Aerosol and Air Quality Research 2021cited by 55position: middledoi
Pulmonary toxicity and gene expression changes after short-term inhalation exposure to surface-modified copper oxide nanoparticles
NanoImpact 2021cited by 37position: lastdoi
Toxicity assessment of industrial engineered and airborne process-generated nanoparticles in a 3D human airway epithelial <i>in vitro</i> model
Nanotoxicology 2021cited by 25position: middledoi
Prenatal air pollution exposure to diesel exhaust induces cardiometabolic disorders in adulthood in a sex-specific manner
Environmental Research 2021cited by 24position: middledoi
Safe by design (SbD) and nanotechnology: a much-discussed topic with a prudence?
Particle and Fibre Toxicology 2021cited by 21position: lastdoi
In Vitro Toxicity of Industrially Relevant Engineered Nanoparticles in Human Alveolar Epithelial Cells: Air–Liquid Interface versus Submerged Cultures
Nanomaterials 2021cited by 21position: middledoi
In vitro hazard characterization of simulated aircraft cabin bleed-air contamination in lung models using an air-liquid interface (ALI) exposure system
Environment International 2021cited by 19position: lastdoi
Inflammatory response in human alveolar epithelial cells after TiO2 NPs or ZnO NPs exposure: Inhibition of surfactant protein A expression as an indicator for loss of lung function
Environmental Toxicology and Pharmacology 2021cited by 17position: middledoi
Mechanism of Action of TiO<sub>2</sub>: Recommendations to Reduce Uncertainties Related to Carcinogenic Potential
The Annual Review of Pharmacology and Toxicology 2020cited by 66position: lastdoi
Optimization of an air-liquid interface in vitro cell co-culture model to estimate the hazard of aerosol exposures
Journal of Aerosol Science 2020cited by 66position: lastdoi
Effects of short-term exposures to ultrafine particles near an airport in healthy subjects
Environment International 2020cited by 63position: lastdoi
Nanoparticle exposure and hazard in the ceramic industry: an overview of potential sources, toxicity and health effects
Environmental Research 2020cited by 58position: middledoi
Comparative toxicity of ultrafine particles around a major airport in human bronchial epithelial (Calu-3) cell model at the air–liquid interface
Toxicology in Vitro 2020cited by 41position: lastdoi
Evaluation of neurological effects of cerium dioxide nanoparticles doped with different amounts of zirconium following inhalation exposure in mouse models of Alzheimer's and vascular disease
Neurochemistry International 2020cited by 34position: middledoi

Grants

No grants ingested yet.

Frequent collaborators

Nicole Janssen · Utrecht University19 papers (2012–2020)Ilse Gosens · National Institute for Public Health and the Environment18 papers (2012–2024)Bert Brunekreef · Utrecht University13 papers (2012–2017)Hedwig Braakhuis · National Institute for Public Health and the Environment10 papers (2014–2024)Paul Fokkens · National Institute for Public Health and the Environment10 papers (2014–2024)Miriam E. Gerlofs-Nijland · National Institute for Public Health and the Environment10 papers (2012–2025)Daan L. A. C. Leseman · National Institute for Public Health and the Environment10 papers (2013–2024)Gerard Hoek · Utrecht University9 papers (2012–2014) · 9 papers (2015–2025)Wim H. de Jong · National Institute for Public Health and the Environment9 papers (2014–2021)Roy M. Harrison · University of Birmingham9 papers (2012–2014)Maaike Steenhof · Utrecht University8 papers (2012–2017)Maciej Strak · Utrecht University8 papers (2012–2017)Frank J. Kelly · Imperial College London7 papers (2012–2014)Aileen Yang · Utrecht University7 papers (2013–2016)Thomas A. J. Kuhlbusch · University of Duisburg-Essen7 papers (2013–2016) · 7 papers (2014–2022)Mark R. Miller · World Heart Federation7 papers (2012–2024) · 6 papers (2015–2023)A. John F. Boere · National Institute for Public Health and the Environment6 papers (2017–2024)