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George D. Demetri

Harvard University · US
Area of research
Pulmonary and Respiratory Medicine · Gastroenterology
Research interest
Research interests include Sarcoma Diagnosis and Treatment, Gastrointestinal Tumor Research and Treatment, Lung Cancer Treatments and Mutations, and Gastric Cancer Management and Outcomes.
h-index
114
citations
63,827
works
637
NIH funding
primary concept
Medicine
email

Recent publications

Afamitresgene autoleucel for advanced synovial sarcoma and myxoid round cell liposarcoma (SPEARHEAD-1): an international, open-label, phase 2 trial
The Lancet 2024cited by 248position: middledoi
Improving Collection and Analysis of Overall Survival Data
Clinical Cancer Research 2024cited by 16position: middledoi
Larotrectinib efficacy and safety in adult patients with tropomyosin receptor kinase fusion sarcomas
Cancer 2023cited by 23position: middledoi
Racial Disparities in COVID-19 Outcomes Among Black and White Patients With Cancer
JAMA Network Open 2022cited by 71position: middledoi
Biomarker correlates with response to NY-ESO-1 TCR T cells in patients with synovial sarcoma
Nature Communications 2022cited by 51position: middledoi
Retrospective observational studies in ultra-rare sarcomas: A consensus paper from the Connective Tissue Oncology Society (CTOS) community of experts on the minimum requirements for the evaluation of activity of systemic treatments
Cancer Treatment Reviews 2022cited by 27position: middledoi
Ultra‐rare sarcomas: A consensus paper from the Connective Tissue Oncology Society community of experts on the incidence threshold and the list of entities
Cancer 2021cited by 221position: middledoi
Association of Convalescent Plasma Therapy With Survival in Patients With Hematologic Cancers and COVID-19
JAMA Oncology 2021cited by 184position: middledoi
First-in-Human Phase I Study of ABBV-085, an Antibody–Drug Conjugate Targeting LRRC15, in Sarcomas and Other Advanced Solid Tumors
Clinical Cancer Research 2021cited by 73position: firstdoi
Cardiac safety of trabectedin monotherapy or in combination with pegylated liposomal doxorubicin in patients with sarcomas and ovarian cancer
Cancer Medicine 2021cited by 12position: lastdoi
Tazemetostat in advanced epithelioid sarcoma with loss of INI1/SMARCB1: an international, open-label, phase 2 basket study
The Lancet Oncology 2020cited by 399position: middledoi
The Angiosarcoma Project: enabling genomic and clinical discoveries in a rare cancer through patient-partnered research
Nature Medicine 2020cited by 270position: middledoi
Diagnosis and management of tropomyosin receptor kinase (TRK) fusion sarcomas: expert recommendations from the World Sarcoma Network
Annals of Oncology 2020cited by 145position: firstdoi
Efficacy and safety of entrectinib in patients (pts) with <i>NTRK</i>-fusion positive (<i>NTRK</i>-fp) solid tumors: An updated integrated analysis.
Journal of Clinical Oncology 2020cited by 34position: lastdoi
Safety and activity of autologous T cells with enhanced NY-ESO-1–specific T-cell receptor (GSK3377794) in HLA-a*02<sup>+</sup> previously-treated and -untreated patients with advanced metastatic/unresectable synovial sarcoma: A master protocol study design (IGNYTE-ESO).
Journal of Clinical Oncology 2020cited by 2position: middledoi
Entrectinib in patients with advanced or metastatic NTRK fusion-positive solid tumours: integrated analysis of three phase 1–2 trials
The Lancet Oncology 2019cited by 1,726position: lastdoi
Altered chromosomal topology drives oncogenic programs in SDH-deficient GISTs
Nature 2019cited by 258position: middledoi
Systemic and local immunity following adoptive transfer of NY-ESO-1 SPEAR T cells in synovial sarcoma
Journal for ImmunoTherapy of Cancer 2019cited by 145position: middledoi
Safety and efficacy of tazemetostat, a first-in-class EZH2 inhibitor, in patients (pts) with epithelioid sarcoma (ES) (NCT02601950).
Journal of Clinical Oncology 2019cited by 66position: middledoi
Entrectinib in NTRK fusion-positive non-small cell lung cancer (NSCLC): Integrated analysis of patients (pts) enrolled in STARTRK-2, STARTRK-1 and ALKA-372-001
Annals of Oncology 2019cited by 44position: lastdoi
First-in-human phase 1 study of ABBV-085, an antibody-drug conjugate (ADC) targeting LRRC15, in sarcomas and other advanced solid tumors.
Journal of Clinical Oncology 2019cited by 15position: firstdoi
Efficacy of Larotrectinib in <i>TRK</i> Fusion–Positive Cancers in Adults and Children
New England Journal of Medicine 2018cited by 2,704position: middledoi
Efficacy and safety of entrectinib in patients with NTRK fusion-positive (NTRK-fp) Tumors: Pooled analysis of STARTRK-2, STARTRK-1 and ALKA-372-001
Annals of Oncology 2018cited by 64position: firstdoi
SMARCB1 is required for widespread BAF complex–mediated activation of enhancers and bivalent promoters
Nature Genetics 2017cited by 293position: middledoi
Activity of Eribulin in Patients With Advanced Liposarcoma Demonstrated in a Subgroup Analysis From a Randomized Phase III Study of Eribulin Versus Dacarbazine
Journal of Clinical Oncology 2017cited by 166position: firstdoi
Correlation of Long-term Results of Imatinib in Advanced Gastrointestinal Stromal Tumors With Next-Generation Sequencing Results
JAMA Oncology 2017cited by 125position: middledoi
Eribulin versus dacarbazine in previously treated patients with advanced liposarcoma or leiomyosarcoma: a randomised, open-label, multicentre, phase 3 trial
The Lancet 2016cited by 759position: middledoi
Long-term follow-up results of the multicenter phase II trial of regorafenib in patients with metastatic and/or unresectable GI stromal tumor after failure of standard tyrosine kinase inhibitor therapy
Annals of Oncology 2016cited by 162position: middledoi
Correlation of KIT and PDGFRA mutational status with clinical benefit in patients with gastrointestinal stromal tumor treated with sunitinib in a worldwide treatment-use trial
BMC Cancer 2016cited by 63position: middledoi
Dose-escalation study of a second-generation non-ansamycin HSP90 inhibitor, onalespib (AT13387), in combination with imatinib in patients with metastatic gastrointestinal stromal tumour
European Journal of Cancer 2016cited by 30position: middledoi

Grants

No grants ingested yet.

Frequent collaborators

Jean‐Yves Blay · International Network for Economic, Social and Cultural Rights18 papers (2012–2020)Patrick Schöffski · Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori12 papers (2012–2019)Robert G. Maki · Media Working Group9 papers (2012–2017)Peter Reichardt · Cornell University9 papers (2012–2016)Sant P. Chawla · Sarcoma Oncology Center8 papers (2012–2019)Hans Gelderblom · University Medical Center8 papers (2012–2016)Piotr Rutkowski · Maria Curie-Skłodowska University7 papers (2012–2016)Margaret von Mehren · Temple University Health System7 papers (2012–2021)Axel Le Cesne · Institut Gustave Roussy7 papers (2012–2016)Michael C. Heinrich · Oregon Health & Science University6 papers (2012–2017)Yoon‐Koo Kang · Ulsan College6 papers (2012–2016)Andrew J. Wagner · Dana-Farber Cancer Institute5 papers (2012–2016)Brian A. Van Tine · Jewish Hospital5 papers (2017–2022)Paolo G. Casali · Fondazione IRCCS Istituto Nazionale dei Tumori5 papers (2012–2012)Antoîne Italiano · Institut Bergonié4 papers (2015–2019)Edwin Choy · Harvard University4 papers (2012–2016)Axel Le Cesne · KU Leuven4 papers (2012–2016)Christopher L. Corless · Université de Sherbrooke4 papers (2012–2017)Jonathan A. Fletcher · University of Pittsburgh Medical Center4 papers (2012–2016)Peter Hohenberger · Heidelberg University4 papers (2012–2016)