Area of research
Endocrine and Autonomic Systems · Nutrition and Dietetics
Research interest
Research topics from publications: Central and peripheral GLP-1 systems independently suppress eating; Central and peripheral GLP-1 systems independently and additively suppress eating. Representative work: Abstract The anorexigenic peptide glucagon-like peptide-1 (GLP-1) is secreted from gut enteroendocrine cells and brain preproglucagon (PPG) neurons, which respectively define the peripheral and central GLP-1 systems. As peripheral satiation signals are integrated in the nucleus tractus solitarius (NTS), PPG NTS neurons are assumed to link the peripheral and central GLP-1 systems, forming a unified GLP-1 gut-brain satiation circuit. This hypothesis, however, remains unsubstantiated. We report that PPG NTS neurons encode satiation in mice, consistent with vagal gastrointestinal distension signalling. However, PPG NTS neurons predominantly receive vagal input from oxytocin receptor-expressing v