Area of research
Cellular and Molecular Neuroscience · Physiology
Research interest
Research interests include Nerve injury and regeneration, Pain Mechanisms and Treatments, Signaling Pathways in Disease, and Hereditary Neurological Disorders.
Schwann cell Lrp1 deletion drives trigeminal neuron sensitization and orofacial pain by modulating mitochondrial function and TRPV1/TRPA1 activity.
Axon-derived PACSIN1 binds to the Schwann cell survival receptor, LRP1, and transactivates TrkC to promote gliatrophic activities.
Cover Image, Volume 72, Issue 5
Brain organoids, consciousness, ethics and moral status
Advances in Head and Neck Cancer Pain
Tumor necrosis factor receptor-1 is selectively sequestered into Schwann cell extracellular vesicles where it functions as a TNFα decoy.
Cellular prion protein in human plasma-derived extracellular vesicles promotes neurite outgrowth via the NMDA receptor-LRP1 receptor system.
Peripheral nerve injury and sensitization underlie pain associated with oral cancer perineural invasion
Assessing Neuronal and Astrocyte Derived Exosomes From Individuals With Mild Traumatic Brain Injury for Markers of Neurodegeneration and Cytotoxic Activity
LRP1 deficiency in microglia blocks neuro‐inflammation in the spinal dorsal horn and neuropathic pain processing
LRP1 deficiency in microglia blocks neuro-inflammation in the spinal dorsal horn and neuropathic pain processing.
Tissue-type plasminogen activator regulates macrophage activation and innate immunity
LDL Receptor–Related Protein-1
Schwann Cell LRP1 Regulates Remak Bundle Ultrastructure and Axonal Interactions to Prevent Neuropathic Pain