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Alexa B. Schrock

GlobalFoundries (United States) · US
Area of research
Pulmonary and Respiratory Medicine · Cancer Research
Research interest
Research interests include Lung Cancer Treatments and Mutations, Cancer Genomics and Diagnostics, Colorectal Cancer Treatments and Studies, and HER2/EGFR in Cancer Research.
h-index
60
citations
17,476
works
815
NIH funding
primary concept
Medicine
email

Recent publications

Association of circulating tumor DNA (ctDNA) variant allelic frequency (VAF) with outcomes on matched targeted therapies (TT) in advanced non-small cell lung cancer (aNSCLC).
Journal of Clinical Oncology 2025cited by 2position: middledoi
Immune checkpoint inhibitors for POLE or POLD1 proofreading-deficient metastatic colorectal cancer
Annals of Oncology 2024cited by 69position: middledoi
Activating Point Mutations in the <i>MET</i> Kinase Domain Represent a Unique Molecular Subset of Lung Cancer and Other Malignancies Targetable with MET Inhibitors
Cancer Discovery 2024cited by 24position: middledoi
Effectiveness of PARP Inhibitor Maintenance Therapy in Ovarian Cancer by BRCA1/2 and a Scar-Based HRD Signature in Real-World Practice
Clinical Cancer Research 2024cited by 22position: middledoi
<i>RAS/RAF</i> Comutation and <i>ERBB2</i> Copy Number Modulates HER2 Heterogeneity and Responsiveness to HER2-directed Therapy in Colorectal Cancer
Clinical Cancer Research 2024cited by 8position: middledoi
Circulating Tumor DNA Enables Sensitive Detection of Actionable Gene Fusions and Rearrangements Across Cancer Types
Clinical Cancer Research 2023cited by 45position: middledoi
Real-World comprehensive genomic profiling data for diagnostic clarity in pulmonary Large-Cell neuroendocrine carcinoma
Lung Cancer 2023cited by 16position: middledoi
Comprehensive genomic profiling and treatment patterns across ancestries in advanced prostate cancer: a large-scale retrospective analysis
The Lancet Digital Health 2023cited by 16position: middledoi
Unique Spectrum of Activating <i>BRAF</i> Alterations in Prostate Cancer
Clinical Cancer Research 2023cited by 15position: middledoi
The Molecular, Immunologic, and Clinicodemographic Landscape of MYC-Amplified Advanced Prostate Cancer
Clinical Genitourinary Cancer 2023cited by 6position: middledoi
Tumor Fraction Correlates With Detection of Actionable Variants Across &gt; 23,000 Circulating Tumor DNA Samples
JCO Precision Oncology 2022cited by 97position: middledoi
Comparative Effectiveness of Immune Checkpoint Inhibitors vs Chemotherapy by Tumor Mutational Burden in Metastatic Castration-Resistant Prostate Cancer
JAMA Network Open 2022cited by 87position: middledoi
Epidermal Growth Factor Receptor Inhibition in Epidermal Growth Factor Receptor–Amplified Gastroesophageal Cancer: Retrospective Global Experience
Journal of Clinical Oncology 2022cited by 25position: middledoi
Structure-based classification predicts drug response in EGFR-mutant NSCLC
Nature 2021cited by 438position: middledoi
Clinicopathologic Features and Response to Therapy of<i>NRG1</i>Fusion–Driven Lung Cancers: The eNRGy1 Global Multicenter Registry
Journal of Clinical Oncology 2021cited by 78position: middledoi
U.S. Phase I First-in-human Study of Taletrectinib (DS-6051b/AB-106), a ROS1/TRK Inhibitor, in Patients with Advanced Solid Tumors
Clinical Cancer Research 2020cited by 107position: middledoi
Profiling of 3,634 cholangiocarcinomas (CCA) to identify genomic alterations (GA), tumor mutational burden (TMB), and genomic loss of heterozygosity (gLOH).
Journal of Clinical Oncology 2019cited by 61position: middledoi
The Pan-Cancer Landscape of Coamplification of the Tyrosine Kinases KIT, KDR, and PDGFRA
The Oncologist 2019cited by 28position: middledoi
<i>FGFR2</i>-Altered Gastroesophageal Adenocarcinomas Are an Uncommon Clinicopathologic Entity with a Distinct Genomic Landscape
The Oncologist 2019cited by 25position: middledoi
<i>STK11/LKB1</i> Mutations and PD-1 Inhibitor Resistance in <i>KRAS</i>-Mutant Lung Adenocarcinoma
Cancer Discovery 2018cited by 1,588position: middledoi
Receptor Tyrosine Kinase Fusions and BRAF Kinase Fusions are Rare but Actionable Resistance Mechanisms to EGFR Tyrosine Kinase Inhibitors
Journal of Thoracic Oncology 2018cited by 135position: firstdoi
Targeted Therapies for Targeted Populations: Anti-EGFR Treatment for <i>EGFR</i> -Amplified Gastroesophageal Adenocarcinoma
Cancer Discovery 2018cited by 119position: middledoi
Hybrid Capture–Based Genomic Profiling of Circulating Tumor DNA from Patients with Advanced Cancers of the Gastrointestinal Tract or Anus
Clinical Cancer Research 2018cited by 71position: firstdoi
Hybrid Capture-Based Comprehensive Genomic Profiling Identifies Lung Cancer Patients with Well-Characterized Sensitizing Epidermal Growth Factor Receptor Point Mutations That Were Not Detected by Standard of Care Testing
The Oncologist 2018cited by 13position: middledoi
PD60-01 CASTRATE RESISTANT TMPRSS2: ERG FUSION POSITIVE AND TMPRSS2: ERG WILD TYPE REFRACTORY ACINAR AND NEUROENDOCRINE PROSTATE CANCER DIFFER IN GENOMIC SIGNATURES AND OPPORTUNITIES FOR TARGETED AND IMMUNOTHERAPIES
The Journal of Urology 2018cited by 0position: middledoi
Analysis of 100,000 human cancer genomes reveals the landscape of tumor mutational burden
Genome Medicine 2017cited by 3,717position: middledoi
Comprehensive Genomic Profiling of 282 Pediatric Low- and High-Grade Gliomas Reveals Genomic Drivers, Tumor Mutational Burden, and Hypermutation Signatures
The Oncologist 2017cited by 289position: middledoi
Identification of <i>NTRK</i> fusions in pediatric mesenchymal tumors
Pediatric Blood & Cancer 2017cited by 105position: middledoi
Hybrid capture-based genomic profiling of circulating tumor DNA from patients with estrogen receptor-positive metastatic breast cancer
Annals of Oncology 2017cited by 89position: middledoi
Novel PDGFRB fusions in childhood B- and T-acute lymphoblastic leukemia
Leukemia 2017cited by 24position: middledoi

Grants

No grants ingested yet.

Frequent collaborators

Jeffrey S. Ross · SUNY Upstate Medical University11 papers (2016–2022)Siraj M. Ali · Lutron Electronics (United States)11 papers (2016–2019)Vincent A. Miller · Universidad San Carlos9 papers (2016–2019)Garrett M. Frampton · GlobalFoundries (United States)6 papers (2016–2023)Philip J. Stephens · Indiana University – Purdue University Indianapolis6 papers (2016–2018)Russell W. Madison · Foundation Medicine (United States)6 papers (2018–2025)Ryon P. Graf · Boston University5 papers (2022–2024)Dean C. Pavlick · Foundation Medicine (United States)5 papers (2017–2023)Geoffrey R. Oxnard · Boston Medical Center5 papers (2022–2023)Jon Chung · National Heart Lung and Blood Institute4 papers (2017–2019)Sai‐Hong Ignatius Ou · University of California, Irvine Medical Center4 papers (2016–2020)Laurie M. Gay · Cancer Research UK Cambridge Center4 papers (2017–2018)Hanna Tukachinsky · Foundation Medicine (United States)4 papers (2022–2023)Richard S.P. Huang · TGS (United Kingdom)4 papers (2022–2025)Samuel J. Klempner · Broad Institute3 papers (2018–2019)Brandon A. Mahal · University of Miami3 papers (2023–2023)Rachel Erlich · Blueprint Medicines (United States)3 papers (2016–2022)James Suh · Foundation Medicine (United States)3 papers (2016–2018) · 3 papers (2022–2023)Julia A. Elvin · Biomedical Research Foundation3 papers (2018–2024)