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James C. Sacchettini

Texas A&M University · US
Area of research
Infectious Diseases · Molecular Biology · graph neural network drug discovery
Research interest
Research interests include Tuberculosis Research and Epidemiology, Enzyme Structure and Function, Biochemical and Molecular Research, and Mycobacterium research and diagnosis.
h-index
94
citations
30,843
works
384
NIH funding
primary concept
email

Recent publications

SuFEx-based antitubercular compound irreversibly inhibits Pks13
Nature 2025cited by 15position: middledoi
Discovery of natural-product-derived sequanamycins as potent oral anti-tuberculosis agents
Cell 2023cited by 22position: middledoi
CinA mediates multidrug tolerance in Mycobacterium tuberculosis
Nature Communications 2022cited by 52position: middledoi
The Tuberculosis Drug Accelerator at year 10: what have we learned?
Nature Medicine 2021cited by 62position: middledoi
Bedaquiline reprograms central metabolism to reveal glycolytic vulnerability in Mycobacterium tuberculosis
Nature Communications 2020cited by 88position: middledoi
Aspartate aminotransferase Rv3722c governs aspartate-dependent nitrogen metabolism in Mycobacterium tuberculosis
Nature Communications 2020cited by 73position: middledoi
Opposing reactions in coenzyme A metabolism sensitize <i>Mycobacterium tuberculosis</i> to enzyme inhibition
Science 2019cited by 66position: middledoi
Advancing Translational Science for Pulmonary Nontuberculous Mycobacterial Infections. A Road Map for Research
American Journal of Respiratory and Critical Care Medicine 2018cited by 64position: middledoi
Development of a Novel Lead that Targets M. tuberculosis Polyketide Synthase 13
Cell 2017cited by 182position: lastdoi
Glyoxylate detoxification is an essential function of malate synthase required for carbon assimilation in <i>Mycobacterium tuberculosis</i>
Proceedings of the National Academy of Sciences 2017cited by 97position: middledoi
Ribosomal mutations promote the evolution of antibiotic resistance in a multidrug environment
eLife 2017cited by 80position: middledoi
Discovery of Novel Oral Protein Synthesis Inhibitors of Mycobacterium tuberculosis That Target Leucyl-tRNA Synthetase
Antimicrobial Agents and Chemotherapy 2016cited by 120position: middledoi
Peptidoglycan synthesis in <i>Mycobacterium tuberculosis</i> is organized into networks with varying drug susceptibility
Proceedings of the National Academy of Sciences 2015cited by 95position: middledoi
The Copper-Responsive RicR Regulon Contributes to Mycobacterium tuberculosis Virulence
mBio 2014cited by 89position: middledoi
Sterilization of granulomas is common in active and latent tuberculosis despite within-host variability in bacterial killing
Nature Medicine 2013cited by 545position: middledoi
Tryptophan Biosynthesis Protects Mycobacteria from CD4 T-Cell-Mediated Killing
Cell 2013cited by 363position: middledoi
Identification of New Drug Targets and Resistance Mechanisms in Mycobacterium tuberculosis
PLoS ONE 2013cited by 251position: lastdoi
Perturbation of Cytochrome <i>c</i> Maturation Reveals Adaptability of the Respiratory Chain in Mycobacterium tuberculosis
mBio 2013cited by 72position: middledoi
Global Assessment of Genomic Regions Required for Growth in Mycobacterium tuberculosis
PLoS Pathogens 2012cited by 249position: middledoi
Novel diaryl ureas with efficacy in a mouse model of malaria
Bioorganic & Medicinal Chemistry Letters 2012cited by 25position: middledoi

Grants

Acquisition of a high-Resolution Data Collection System
NSF0521553$684,2002005–2008PIRePORTER

Frequent collaborators

Thomas R. Ioerger · Mitchell Institute9 papers (2012–2017)Eric J. Rubin · Brigham and Women's Hospital5 papers (2012–2020)Christopher M. Sassetti · Massachusetts Academy of Math and Science at WPI4 papers (2012–2018)Kyu Y. Rhee · Cornell University3 papers (2017–2022)Sabine Ehrt · Cornell University3 papers (2013–2022)Inna V. Krieger · Texas A&M University3 papers (2017–2022)Yanjia J. Zhang · Brigham and Women's Hospital2 papers (2012–2013)Véronique Dartois · Hackensack Meridian Health2 papers (2013–2022)Curtis Huttenhower · Harvard University2 papers (2012–2013)Robert S. Jansen · Radboud University Nijmegen2 papers (2020–2022)Dirk Schnappinger · Cornell University2 papers (2017–2022)Kristine M. Guinn · University of Massachusetts Chan Medical School2 papers (2013–2020)Jarukit E. Long · University of Massachusetts Amherst2 papers (2012–2015)Bavesh D Kana · National Health Laboratory Service1 papers (2013–2013)Stacy Galaviz · Texas A&M University1 papers (2013–2013)Jansy P. Sarathy · Hackensack Meridian Health1 papers (2022–2022) · 1 papers (2020–2020)Diane Ordway · Colorado State University1 papers (2018–2018)Matthew K. Waldor · Brigham and Women's Hospital1 papers (2015–2015)Kaj M. Kreutzfeldt · Cornell University1 papers (2022–2022)