Yiying She

Area of research

Molecular Medicine · Food Science

Research interest

Research topics from publications: Emergence of chromosomally located blaCTX-M-14b and qnrS1 in Salmonella enterica serotype Kentucky ST198 in China; Genomic Epidemiology and Antimicrobial Susceptibility Profile of Enterotoxigenic Escherichia coli From Outpatients With Diarrhea in Shenzhen, China, 2015–2020; Population dynamics and antimicrobial resistance of Salmonella Derby ST40 from Shenzhen, China. Representative work: Highly fluoroquinolone-resistant Salmonella enterica serotype Kentucky (S. Kentucky) has been widespread in recent years, largely associated with the spread of the ST (sequence type) 198, which often leads to multi-drug resistance (MDR). The genomic epidemiology research of S. Kentucky in China is rare and needs to be conducted. We analyzed the genomic epidemiology and antimicrobial characteristics of S. Kentucky ST198 collected from foodborne disease surveillance in Shenzhen, China, during 2010–2021, using whole genome sequencing and antibiotic sensitivity test, and 158 global S. Kentucky genomes ST198 were included to compare. Among the 8,559 Salmonella isolates, 43 S. Kentucky ST198 isola Enterotoxigenic Escherichia coli (ETEC) is the leading cause of severe diarrhea in children and the most common cause of diarrhea in travelers. However, most ETEC infections in Shenzhen, China were from indigenous adults. In this study, we characterized 106 ETEC isolates from indigenous outpatients with diarrhea (77% were adults aged >20 years) in Shenzhen between 2015 and 2020 by whole-genome sequencing and antimicrobial susceptibility testing. Shenzhen ETEC isolates showed a remarkable high diversity, which belonged to four E. coli phylogroups (A: 71%, B1: 13%, E: 10%, and D: 6%) and 15 ETEC lineages, with L11 (25%, O159:H34/O159:H43, ST218/ST3153), novel L2/4 (21%, O6:H16, ST48), and L