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Wen Zhou

Merck & Co., Inc., Rahway, NJ, USA (United States) · US
Area of research
Genetics · Epidemiology
Research interest
Research interests include Inflammatory Bowel Disease, Microscopic Colitis, Multiple Myeloma Research and Treatments, and Pluripotent Stem Cells Research.
h-index
34
citations
3,914
works
161
NIH funding
primary concept
Medicine
email

Recent publications

LGR4 promotes proliferation and homing via activation of the NF‑κB signaling pathway in multiple myeloma
International Journal of Oncology 2025cited by 4position: lastdoi
Biomarkers of pediatric Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis through single-cell transcriptomics.
2025cited by 1position: contributordoi
Targeting the origins of multiple myeloma along hematopoietic stem cell lymphoid lineage differentiation.
2025cited by 1position: contributordoi
Targeting gut microbial nitrogen recycling and cellular uptake of ammonium to improve bortezomib resistance in multiple myeloma.
2024cited by 24position: contributordoi
Efficacy and Safety of Advanced Therapies for Moderately to Severely Active Ulcerative Colitis at Induction and Maintenance: An Indirect Treatment Comparison Using Bayesian Network Meta-analysis
Crohn s & Colitis 360 2023cited by 60position: middledoi
Efficacy and safety of upadacitinib maintenance therapy for moderately to severely active ulcerative colitis in patients responding to 8 week induction therapy (U-ACHIEVE Maintenance): overall results from the randomised, placebo-controlled, double-blind, phase 3 maintenance study
˜The œLancet. Gastroenterology & hepatology 2023cited by 46position: middledoi
Excessive serine from the bone marrow microenvironment impairs megakaryopoiesis and thrombopoiesis in Multiple Myeloma
Nature Communications 2023cited by 40position: lastdoi
A Comparative Evaluation of the Measurement Properties of Three Histological Indices of Mucosal Healing in Ulcerative Colitis: Geboes Score, Robarts Histopathology Index and Nancy Index
Journal of Crohn s and Colitis 2023cited by 37position: middledoi
Excessive serine from the bone marrow microenvironment impairs megakaryopoiesis and thrombopoiesis in Multiple Myeloma.
2023cited by 30position: contributordoi
Correlation of mucosal healing endpoints with long-term clinical and patient-reported outcomes in ulcerative colitis
Journal of Gastroenterology 2023cited by 27position: middledoi
Upadacitinib Induction and Maintenance Therapy Improves Abdominal Pain, Bowel Urgency, and Fatigue in Patients With Ulcerative Colitis: A Post Hoc Analysis of Phase 3 Data
Inflammatory Bowel Diseases 2023cited by 24position: middledoi
The Interaction between Gut Microbiota and Host Amino Acids Metabolism in Multiple Myeloma.
2023cited by 12position: contributordoi
Proline promotes proliferation and drug resistance of multiple myeloma by downregulation of proline dehydrogenase.
2023cited by 11position: contributordoi
Intestinal Microbes and Hematological Malignancies.
2023cited by 7position: contributordoi
Upadacitinib as induction and maintenance therapy for moderately to severely active ulcerative colitis: results from three phase 3, multicentre, double-blind, randomised trials
The Lancet 2022cited by 578position: middledoi
Upadacitinib Therapy Reduces Ulcerative Colitis Symptoms as Early as Day 1 of Induction Treatment
Clinical Gastroenterology and Hepatology 2022cited by 95position: middledoi
Blocking glycine utilization inhibits multiple myeloma progression by disrupting glutathione balance
Nature Communications 2022cited by 74position: lastdoi
Blocking glycine utilization inhibits multiple myeloma progression by disrupting glutathione balance.
2022cited by 57position: contributordoi
Genetic Aberrations and Interaction of NEK2 and TP53 Accelerate Aggressiveness of Multiple Myeloma.
2022cited by 30position: contributordoi
Single-Cell RNA-seq Analysis Reveals Dysregulated Cell-Cell Interactions in a Tumor Microenvironment Related to HCC Development.
2022cited by 7position: contributordoi
OP23 Efficacy and safety of upadacitinib as induction therapy in patients with Moderately to Severely Active Ulcerative Colitis: Results from phase 3 U-ACCOMPLISH study
Journal of Crohn s and Colitis 2021cited by 25position: middledoi
COX2 confers bone marrow stromal cells to promoting TNFα/TNFR1β-mediated myeloma cell growth and adhesion.
2021cited by 8position: contributordoi
Efficacy of Upadacitinib in a Randomized Trial of Patients With Active Ulcerative Colitis
Gastroenterology 2020cited by 275position: middledoi
Alterations of gut microbiome accelerate multiple myeloma progression by increasing the relative abundances of nitrogen-recycling bacteria.
2020cited by 101position: contributordoi
NEK2 induces autophagy-mediated bortezomib resistance by stabilizing Beclin-1 in multiple myeloma.
2020cited by 83position: contributordoi
Phosphoglycerate dehydrogenase promotes proliferation and bortezomib resistance through increasing reduced glutathione synthesis in multiple myeloma.
2020cited by 51position: contributordoi
Cdc37 suppression induces plasma cell immaturation and bortezomib resistance in multiple myeloma via Xbp1s
Oncogenesis 2020cited by 13position: lastdoi
Cdc37 suppression induces plasma cell immaturation and bortezomib resistance in multiple myeloma via Xbp1s.
2020cited by 11position: contributordoi
Detection of recurrent cytogenetic aberrations in multiple myeloma: A comparison between MLPA and iFISH
Oncotarget 2015cited by 20position: middledoi

Grants

Collaborative Research: Statistical Modeling and Inference on Directed Network Data for Understanding Faculty Hiring Dynamics
NSF2515368$100,0002025–2028PIRePORTER
2017 Graybill Conference on Statistical Genomics and Genetics
NSF1730090$15,0002017–2018PIRePORTER
BIGDATA: Collaborative Research: F: IA: Statistical Learning for Big Data with Random Projections
NSF1545994$100,5772015–2018PIRePORTER
Collaborative Research: EAGER:Studying lignocellulosic fine structure and its dynamics in enzymatic hydrolysis of biomass using molecule-recognizing AFM and computational modeling
NSF1138734$44,6702011–2013PIRePORTER

Frequent collaborators

Yuri Sánchez González · AbbVie (United States)8 papers (2021–2023)Silvio Danese · Io Therapeutics (United States)7 papers (2021–2023) · 6 papers (2022–2025)Remo Panaccione · Nutrition-Génétique et Exposition aux Risques Environnementaux6 papers (2021–2023)Dapo Ilo · AbbVie (United States)5 papers (2022–2023)Séverine Vermeire · Europe Hospitals5 papers (2021–2023)Gang An · Harbin Medical University5 papers (2015–2025)Peter Higgins · Michigan Medicine4 papers (2020–2023)Xiangling Feng · Ministry of Education of the People's Republic of China4 papers (2020–2025)Yinghong Zhu · Ministry of Education of the People's Republic of China4 papers (2020–2025)Jiaojiao Guo · Ministry of Education of the People's Republic of China4 papers (2020–2025)Lu Xie · Jiangxi University of Traditional Chinese Medicine4 papers (2020–2025)Wei Jia · Nanjing University of Aeronautics and Astronautics4 papers (2020–2025)Zhenhao Liu · Shanghai Institute for Biomedical and Pharmaceutical Technologies4 papers (2022–2025)Lugui Qiu · Chinese Academy of Medical Sciences & Peking Union Medical College4 papers (2015–2023)Edward V. Loftus · WinnMed4 papers (2021–2023)Geert D’Haens · Vrije Universiteit Amsterdam4 papers (2020–2023)Li J · Hubei University of Technology3 papers (2023–2025)Xuan Yao · South China Agricultural University3 papers (2022–2023)William J. Sandborn · Mirati Therapeutics (United States)3 papers (2020–2022)