Area of research
Cellular and Molecular Neuroscience · Molecular Biology
Research interest
Research topics from publications: Icariin reduces Glu‐induced excitatory neurotoxicity via antioxidative and antiapoptotic pathways in SH‐SY5Y cells. Representative work: Excessive glutamate (Glu) can lead to significant effects on neural cells through the generation of neurotoxic or excitotoxic cascades. Icariin (ICA) is a main active ingredient of Chinese Medicine Berberidaceae epimedium L., and has many biological activities, such as antiinflammation, antioxidative stress, and anti‐depression. This study aims to evaluate the effect of ICA on Glu‐induced excitatory neurotoxicity of SH‐SY5Y cells. The cell viability assay was evaluated by the CCK‐8 assay. The apoptosis, reactive oxygen species (ROS), and mitochondrial membrane potential were assessed by flow cytometry. Intracellular Ca 2+ concentration was determined by using the fluorescent probe Fluo‐3. Pr