Area of research
Epidemiology · General Health Professions
Research interest
Research topics from publications: Static Muscle Stretching Enhances Vascular Responsiveness of the Tibial Nutrient Artery; Exercise training‐induced enhancement of coronary vasodilatory function is absent in rats lacking the transcription factor, Nrf2; Deficiency of the transcription factor, Nrf2, impairs vasomotor responses and limits exercise training‐induced adaptations of coronary arterioles; Adiponectin‐deficient Mice Demonstrate Impaired Coronary Arteriolar Vasodilation and Subsequent Decline in Cardiac Function; Exercise training‐induced adaptations of vascular smooth muscle vasodilatory function are absent in muscle arterioles from rats lacking the nuclear factor (erythroid‐derived 2)‐like 2 (Nrf2) gene; Effects of sex and exercise training on bone volume and density in Nrf2‐deficient rats; The role of adiponectin in exercise training‐induced vascular adaptation. Representative work: The magnitude of bone formation and remodeling is linked to both the magnitude of strain placed on the bone and the perfusion of bone. We have previously shown that daily static stretching of the ankle flexor muscles in aged rats results in increased blood flow to the stretched muscles and to the proximal tibial metaphasis during walking exercise. The purpose of this study was to determine the effects of daily static muscle stretching on vasoreactivity of the nutrient artery that perfuses the proximal tibial metaphasis. Static stretching of ankle flexor muscles was performed in aged male Fischer 344 rats (20 months) by placement of a dorsiflexion splint on the left ankle for 30 min/day, 5d/w Nuclear factor (erythroid‐derived 2)‐like 2 (Nrf2) is a transcription factor that is crucial in maintaining cellular redox homeostasis. Aerobic exercise training has been reported to enhance vasodilatory responses of coronary arterioles through signaling that involves reactive oxygen species. We hypothesized that deletion of Nrf2 would alter vasodilatory responses of coronary arterioles and limit exercise training‐induced adaptations of coronary vasodilatory function. We exercise trained wild type (WT) Sprague‐Dawley rats, and their littermates that were lacking the Nrf2 gene (Nrf2KO). Rats were either exercise trained (EX) on a motor‐driven treadmill 5 days/wk or remained sedentary (SED) in
Static Muscle Stretching Enhances Vascular Responsiveness of the Tibial Nutrient Artery
Exercise training‐induced enhancement of coronary vasodilatory function is absent in rats lacking the transcription factor, Nrf2
Deficiency of the transcription factor, Nrf2, impairs vasomotor responses and limits exercise training‐induced adaptations of coronary arterioles
Adiponectin‐deficient Mice Demonstrate Impaired Coronary Arteriolar Vasodilation and Subsequent Decline in Cardiac Function
Exercise training‐induced adaptations of vascular smooth muscle vasodilatory function are absent in muscle arterioles from rats lacking the nuclear factor (erythroid‐derived 2)‐like 2 (Nrf2) gene
Effects of sex and exercise training on bone volume and density in Nrf2‐deficient rats
The role of adiponectin in exercise training‐induced vascular adaptation