Area of research
Molecular Biology · Neurology
Research interest
Research interests include Pluripotent Stem Cells Research, CRISPR and Genetic Engineering, Amyotrophic Lateral Sclerosis Research, and Neurogenetic and Muscular Disorders Research.
Biomaterial-minimalistic photoactivated bioprinting of cell-dense tissues
TDP-43-dependent mis-splicing of KCNQ2 triggers intrinsic neuronal hyperexcitability in ALS/FTD
High-dimensional phenotyping to define the genetic basis of cellular morphology
Single-nucleus sequencing reveals enriched expression of genetic risk factors in extratelencephalic neurons sensitive to degeneration in ALS
Exposure of iPSC-derived human microglia to brain substrates enables the generation and manipulation of diverse transcriptional states in vitro
Natural variation in gene expression and viral susceptibility revealed by neural progenitor cell villages
Astrocytic cell adhesion genes linked to schizophrenia correlate with synaptic programs in neurons
Evaluating the state of the science for adeno-associated virus integration: An integrated perspective
Molecularly cleavable bioinks facilitate high-performance digital light processing-based bioprinting of functional volumetric soft tissues
The 22q11.2 region regulates presynaptic gene-products linked to schizophrenia
A resource for generating and manipulating human microglial states in vitro
The genetic architecture of DNA replication timing in human pluripotent stem cells
C9orf72 suppresses systemic and neural inflammation induced by gut bacteria
Effect of Ezogabine on Cortical and Spinal Motor Neuron Excitability in Amyotrophic Lateral Sclerosis
Cancer-Related Mutations Identified in Primed Human Pluripotent Stem Cells
Publicly Available hiPSC Lines with Extreme Polygenic Risk Scores for Modeling Schizophrenia
Publicly available hiPSC lines with extreme polygenic risk scores for modeling schizophrenia
ALS-implicated protein TDP-43 sustains levels of STMN2, a mediator of motor neuron growth and repair
Exome sequencing in amyotrophic lateral sclerosis implicates a novel gene, DNAJC7, encoding a heat-shock protein
Dysregulated protocadherin-pathway activity as an intrinsic defect in induced pluripotent stem cell–derived cortical interneurons from subjects with schizophrenia
RETRACTED: Cancer-Related Mutations Identified in Primed and Naive Human Pluripotent Stem Cells
Publisher Correction: Exome sequencing in amyotrophic lateral sclerosis implicates a novel gene, DNAJC7, encoding a heat-shock protein
Combining NGN2 Programming with Developmental Patterning Generates Human Excitatory Neurons with NMDAR-Mediated Synaptic Transmission
All-Optical Electrophysiology for High-Throughput Functional Characterization of a Human iPSC-Derived Motor Neuron Model of ALS
TDP-43 induces p53-mediated cell death of cortical progenitors and immature neurons
A Stem Cell-Based Screening Platform Identifies Compounds that Desensitize Motor Neurons to Endoplasmic Reticulum Stress
All-optical synaptic electrophysiology probes mechanism of ketamine-induced disinhibition
Convergence of independent DISC1 mutations on impaired neurite growth via decreased UNC5D expression
Comparative genomic analysis of embryonic, lineage-converted, and stem cell-derived motor neurons
Human pluripotent stem cells recurrently acquire and expand dominant negative P53 mutations