Area of research
Critical Care and Intensive Care Medicine · Molecular Biology
Research interest
Research interests include Trauma, Hemostasis, Coagulopathy, Resuscitation, Cell death mechanisms and regulation, Renal function and acid-base balance, and Hemodynamic Monitoring and Therapy.
REDD1/DDIT4 counteracts endoplasmic reticulum stress-induced apoptosis by controlling the expression of death receptor TRAILR2/DR5 in cancer cells.
Spatiotemporal dynamics of Mcl-1 abundance and its influence on apoptosis susceptibility
Interplay of ferroptotic and apoptotic cell death and its modulation by BH3-mimetics.
A pH-sensitive binding modality allows successful transferrin receptor-mediated transcytosis of a bivalent antibody across brain barriers.
Stochasticity contributes to explaining minority and majority MOMP during apoptosis
Stochasticity contributes to explaining minority and majority MOMP during apoptosis.
REDD1/DDIT4 counteracts endoplasmic reticulum stress-induced apoptosis by controlling the expression of death receptor TRAILR2/DR5 in cancer cells
BCL-2 and BOK regulate apoptosis by interaction of their C-terminal transmembrane domains.
Why Bax detection in >1400 publications might be flawed.
TRAIL-induced apoptosis and proteasomal activity - Mechanisms, signalling and interplay.
BCL-2 and BOK regulate apoptosis by interaction of their C-terminal transmembrane domains
Interplay of ferroptotic and apoptotic cell death and its modulation by BH3-mimetics
Apoptotic cell death in disease—Current understanding of the NCCD 2023
Applying a GAN-based classifier to improve transcriptome-based prognostication in breast cancer.
An atlas of inter- and intra-tumor heterogeneity of apoptosis competency in colorectal cancer tissue at single-cell resolution.
Glioblastoma, from disease understanding towards optimal cell-based in vitro models.
cFLIP downregulation is an early event required for endoplasmic reticulum stress-induced apoptosis in tumor cells.
ER stress-induced cell death proceeds independently of the TRAIL-R2 signaling axis in pancreatic β cells.
Proteasome inhibition triggers the formation of TRAIL receptor 2 platforms for caspase-8 activation that accumulate in the cytosol.
Melanoma 2.0. Skin cancer as a paradigm for emerging diagnostic technologies, computational modelling and artificial intelligence.
Influences on glycocalyx shedding during the Yukon Arctic Ultra: the longest and the coldest ultramarathon
Mitochondrial genome variations, mitochondrial-nuclear compatibility, and their association with metabolic diseases.
Applying GAN-based data augmentation to improve transcriptome-based prognostication in breast cancer
Marizomib sensitizes primary glioma cells to apoptosis induced by a latest-generation TRAIL receptor agonist.
Transcriptional CDK inhibitors, CYC065 and THZ1 promote Bim-dependent apoptosis in primary and recurrent GBM through cell cycle arrest and Mcl-1 downregulation.
Cell cycle progression and transmitotic apoptosis resistance promote escape from extrinsic apoptosis.
Transcriptional CDK Inhibitors CYC065 and THZ1 Induce Apoptosis in Glioma Stem Cells Derived from Recurrent GBM.
Low-Level Endothelial TRAIL-Receptor Expression Obstructs the CNS-Delivery of Angiopep-2 Functionalised TRAIL-Receptor Agonists for the Treatment of Glioblastoma.
Linking hyperosmotic stress and apoptotic sensitivity.
Development of a protein signature to enable clinical positioning of IAP inhibitors in colorectal cancer.