Area of research
Genetics · Surgery
Research interest
Research interests include Genetic Associations and Epidemiology, Lipoproteins and Cardiovascular Health, Adipokines, Inflammation, and Metabolic Diseases, and Diabetes, Cardiovascular Risks, and Lipoproteins.
Adipose tissue eQTL meta-analysis highlights the contribution of allelic heterogeneity to gene expression regulation and cardiometabolic traits
Single-cell DNA methylome and 3D genome atlas of human subcutaneous adipose tissue
Publisher Correction: Partitioned polygenic risk scores identify distinct types of metabolic dysfunction-associated steatotic liver disease
Partitioned polygenic risk scores identify distinct types of metabolic dysfunction-associated steatotic liver disease
Increased secretion of adipocyte-derived extracellular vesicles is associated with adipose tissue inflammation and the mobilization of excess lipid in human obesity
Age-dependent genes in adipose stem and precursor cells affect regulation of fat cell differentiation and link aging to obesity via cellular and genetic interactions
Single nucleus RNA-sequencing integrated into risk variant colocalization discovers 17 cell-type-specific abdominal obesity genes for metabolic dysfunction-associated steatotic liver disease
A novel long non-coding RNA connects obesity to impaired adipocyte function
Cross-tissue omics analysis discovers ten adipose genes encoding secreted proteins in obesity-related non-alcoholic fatty liver disease
Deep learning-based phenotype imputation on population-scale biobank data increases genetic discoveries
Applying an evolutionary mismatch framework to understand disease susceptibility
Increased body mass index is linked to systemic inflammation through altered chromatin co-accessibility in human preadipocytes
Cell-Type Composition Affects Adipose Gene Expression Associations With Cardiometabolic Traits
Single-cell dissection of the obesity-exercise axis in adipose-muscle tissues implies a critical role for mesenchymal stem cells
Human liver single nucleus and single cell RNA sequencing identify a hepatocellular carcinoma-associated cell-type affecting survival
ACE2 expression in adipose tissue is associated with cardio-metabolic risk factors and cell type composition—implications for COVID-19
Molecular pathways behind acquired obesity: Adipose tissue and skeletal muscle multiomics in monozygotic twin pairs discordant for BMI
Indole-3-Propionic Acid, a Gut-Derived Tryptophan Metabolite, Associates with Hepatic Fibrosis
Differential Mitochondrial Gene Expression in Adipose Tissue Following Weight Loss Induced by Diet or Bariatric Surgery
Identification of 90 NAFLD GWAS loci and establishment of NAFLD PRS and causal role of NAFLD in coronary artery disease
Identification of TBX15 as an adipose master trans regulator of abdominal obesity genes
Fast estimation of genetic correlation for biobank-scale data
Integrative analysis of liver-specific non-coding regulatory SNPs associated with the risk of coronary artery disease
Accurate estimation of cell composition in bulk expression through robust integration of single-cell information
Enhancing droplet-based single-nucleus RNA-seq resolution using the semi-supervised machine learning classifier DIEM
The causal effect of obesity on prediabetes and insulin resistance reveals the important role of adipose tissue in insulin resistance
RIPK1 gene variants associate with obesity in humans and can be therapeutically silenced to reduce obesity in mice
Adiponectin GWAS loci harboring extensive allelic heterogeneity exhibit distinct molecular consequences
A comprehensive study of metabolite genetics reveals strong pleiotropy and heterogeneity across time and context
Adipose Tissue Gene Expression Associations Reveal Hundreds of Candidate Genes for Cardiometabolic Traits