Area of research
Pulmonary and Respiratory Medicine · Physiology
Research interest
Research interests include Medicine, Cystic fibrosis, Organoid, Cystic fibrosis transmembrane conductance regulator, Internal medicine, and Ivacaftor.
OrgaSegment: deep-learning based organoid segmentation to quantify CFTR dependent fluid secretion
Repeatability and reproducibility of the Forskolin-induced swelling (FIS) assay on intestinal organoids from people with Cystic Fibrosis
Early-Life Risk Factors for Carotid Intima-Media Thickness and Carotid Stiffness in Adolescence
Centralized intestinal organoid generation is a feasible and safe approach for personalized medicine as demonstrated in the HIT-CF Europe Organoid Study
Elexacaftor/tezacaftor/ivacaftor efficacy in intestinal organoids with rare CFTR variants in comparison to CFTR-F508del and CFTR-wild type controls
Readthrough compounds for nonsense mutations: bridging the translational gap
FDA-approved drug screening in patient-derived organoids demonstrates potential of drug repurposing for rare cystic fibrosis genotypes
CFTR Function Restoration upon Elexacaftor/Tezacaftor/Ivacaftor Treatment in Patient-Derived Intestinal Organoids with Rare CFTR Genotypes
Defining and Measuring Resilience in Children with a Chronic Disease: a Scoping Review
Exploring intrinsic variability between cultured nasal and bronchial epithelia in cystic fibrosis
Lung function decline preceding chronic respiratory failure in spinal muscular atrophy: a national prospective cohort study
Evidence for Beneficial Effect of Daily Use of Mechanical Insufflation-Exsufflation in Patients With Neuromuscular Diseases
Measuring cystic fibrosis drug responses in organoids derived from 2D differentiated nasal epithelia
Forskolin-induced organoid swelling is associated with long-term cystic fibrosis disease progression
Natural history of respiratory muscle strength in spinal muscular atrophy: a prospective national cohort study
High-throughput functional assay in cystic fibrosis patient-derived organoids allows drug repurposing
Forskolin induced swelling (FIS) assay in intestinal organoids to guide eligibility for compassionate use treatment in a CF patient with a rare genotype
The PROactive cohort study: rationale, design, and study procedures
Drug Repurposing for Cystic Fibrosis: Identification of Drugs That Induce CFTR-Independent Fluid Secretion in Nasal Organoids
Preclinical Aortic Atherosclerosis in Adolescents With Chronic Disease
Drug repurposing for Cystic Fibrosis: identification of drugs that induce CFTR-independent fluid secretion in nasal organoids
Functional Restoration of CFTR Nonsense Mutations in Intestinal Organoids
Individual and Group Response of Treatment with Ivacaftor on Airway and Gut Microbiota in People with CF and a S1251N Mutation
Infant RSV immunoprophylaxis changes nasal epithelial DNA methylation at 6 years of age
CRISPR-Based Adenine Editors Correct Nonsense Mutations in a Cystic Fibrosis Organoid Biobank
Protocol for Application, Standardization and Validation of the Forskolin-Induced Swelling Assay in Cystic Fibrosis Human Colon Organoids
Natural history of lung function in spinal muscular atrophy
Cathelicidin-inspired antimicrobial peptides as novel antifungal compounds
Risk factors for atopic diseases and recurrent respiratory tract infections in children
Comparison of Organoid Swelling and <i>In Vivo</i> Biomarkers of CFTR Function to Determine Effects of Lumacaftor–Ivacaftor in Patients with Cystic Fibrosis Homozygous for the F508del Mutation