Nynke I. Kramer

Drug Metabolism of Hepatocyte-like Organoids and Their Applicability in In Vitro Toxicity Testing

In Silico Methods for Environmental Risk Assessment: Principles, Tiered Approaches, Applications, and Future Perspectives

A regression-based QSAR-model to predict acute toxicity of aromatic chemicals in tadpoles of the Japanese brown frog (Rana japonica): Calibration, validation, and future developments to support risk assessment of chemicals in amphibians

Effective exposure of chemicals in in vitro cell systems: A review of chemical distribution models

Vipers of Major clinical relevance in Europe: Taxonomy, venom composition, toxicology and clinical management of human bites

Safer chemicals using less animals: kick-off of the European ONTOX project

Bioprinting of Human Liver‐Derived Epithelial Organoids for Toxicity Studies

Modelling human variability in toxicokinetic and toxicodynamic processes using Bayesian meta‐analysis, physiologically‐based modelling and in vitro systems

Application of in vitro data in physiologically-based kinetic models for quantitative in vitro-in vivo extrapolation: A case-study for baclofen

HiPSC-Derived Hepatocyte-like Cells Can Be Used as a Model for Transcriptomics-Based Study of Chemical Toxicity

Human variability in isoform-specific UDP-glucuronosyltransferases: markers of acute and chronic exposure, polymorphisms and uncertainty factors

Integrating QSAR models predicting acute contact toxicity and mode of action profiling in honey bees (A. mellifera): Data curation using open source databases, performance testing and validation

Acetylcholinesterase inhibition in electric eel and human donor blood: an in vitro approach to investigate interspecies differences and human variability in toxicodynamics

QSAR Models for Human Carcinogenicity: An Assessment Based on Oral and Inhalation Slope Factors

Animal-free strategies in food safety & nutrition: What are we waiting for? Part I: Food safety

The use of adverse outcome pathways in the safety evaluation of food additives

Investigating combined toxicity of binary mixtures in bees: Meta-analysis of laboratory tests, modelling, mechanistic basis and implications for risk assessment

Predicting acute contact toxicity of organic binary mixtures in honey bees (A. mellifera) through innovative QSAR models

Characterizing the coverage of critical effects relevant in the safety evaluation of food additives by AOPs

Time-Resolved Freely Dissolved Concentrations of Semivolatile and Hydrophobic Test Chemicals in In Vitro Assays—Measuring High Losses and Crossover by Headspace Solid-Phase Microextraction

Next generation physiologically based kinetic (NG-PBK) models in support of regulatory decision making

Modelling survival: exposure pattern, species sensitivity and uncertainty

Biokinetics in repeated-dosing in vitro drug toxicity studies

An alkaline phosphatase transport mechanism in the pathogenesis of Alzheimer’s disease and neurodegeneration

Dose metric considerations in in vitro assays to improve quantitative in vitro–in vivo dose extrapolations

PBTK modelling platforms and parameter estimation tools to enable animal-free risk assessment

Acute toxicity of the cationic surfactant C12-benzalkonium in different bioassays: How test design affects bioavailability and effect concentrations

A novel hypothesis for an alkaline phosphatase ‘rescue’ mechanism in the hepatic acute phase immune response

Predicting Adult Fish Acute Lethality with the Zebrafish Embryo: Relevance of Test Duration, Endpoints, Compound Properties, and Exposure Concentration Analysis

Quantifying Processes Determining the Free Concentration of Phenanthrene in Basal Cytotoxicity Assays