U.S. National Science Foundation · US
Area of research
Surgery · Oncology
Research interest
Research interests include Pancreatitis Pathology and Treatment, Pancreatic and Hepatic Oncology Research, Pancreatic function and diabetes, and Gastrointestinal disorders and treatments.
Minigenes for heterologous expression of human and mouse cationic trypsinogen.
Mutations of Gly277 in <i>CPA1</i>-related chronic pancreatitis: clinical clues for misfolding aetiology.
Chymotrypsin Deficiency Accelerates Precancerous Remodeling of the Pancreas in KC Mice.
AlphaMissense versus laboratory-based pathogenicity prediction of 13 novel missense <i>CPA1</i> variants from pancreatitis cases.
Chronic pancreatitis in T7C140S mice with misfolding cationic trypsinogen mutant.
Misfolding PRSS1 variant p.Ala61Val in a case of suspected intrauterine pancreatitis.
Misfolding <i>CPA1</i> mutation accelerates precancerous pancreas lesions in <i>KC</i> mice.
Chymotrypsin B2 (CTRB2) Deletion Variant Induces Endoplasmic Reticulum Stress but does not Increase Risk for Chronic Pancreatitis.
Heterozygous Spink1 Deficiency Promotes Trypsin-dependent Chronic Pancreatitis in Mice
Heterozygous Spink1 Deficiency Promotes Trypsin-dependent Chronic Pancreatitis in Mice.
Functional predictors of pathogenicity of missense <i>CPA1</i> variants in chronic pancreatitis.
Secretagogue-induced pancreatitis in mice devoid of chymotrypsin.
Novel chymotrypsin C (CTRC) variants from real-world genetic testing of pediatric chronic pancreatitis cases.
Intron-mediated enhancement of SPINK1 expression for pancreatitis therapy.
Trypsin Activity in Secretagogue-induced Murine Pancreatitis Is Solely Elicited by Cathepsin B and Does Not Mediate Key Pathologic Responses
Substrate specificity of human chymotrypsin-like protease (CTRL) characterized by phage display-selected small-protein inhibitors.
Mouse model of PRSS1 p.R122H-related hereditary pancreatitis highlights context-dependent effect of autolysis-site mutation.
Risk of chronic pancreatitis in carriers of the c.180C>T (p.Gly60=) CTRC variant: case-control studies and meta-analysis.
Modelling chronic pancreatitis as a complex genetic disease in mice.
Preclinical testing of dabigatran in trypsin-dependent pancreatitis
Arg236 in human chymotrypsin B2 (CTRB2) is a key determinant of high enzyme activity, trypsinogen degradation capacity, and protection against pancreatitis
Loss-of-function variant in chymotrypsin like elastase 3B (CELA3B) is associated with non-alcoholic chronic pancreatitis
Preclinical testing of dabigatran in trypsin-dependent pancreatitis.
Rate of Autoactivation Determines Pancreatitis Phenotype in Trypsinogen Mutant Mice.
Novel p.G250A Mutation Associated with Chronic Pancreatitis Highlights Misfolding-Prone Region in Carboxypeptidase A1 (CPA1)
Novel p.G250A Mutation Associated with Chronic Pancreatitis Highlights Misfolding-Prone Region in Carboxypeptidase A1 (CPA1).
Chronic progression of cerulein-induced acute pancreatitis in trypsinogen mutant mice.
Variants in the pancreatic CUB and zona pellucida-like domains 1 (CUZD1) gene in early-onset chronic pancreatitis - A possible new susceptibility gene.
Bicarbonate defective CFTR variants increase risk for chronic pancreatitis: A meta-analysis.
Defective binding of SPINK1 variants is an uncommon mechanism for impaired trypsin inhibition in chronic pancreatitis