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Douglas L. Arnold

Montreal Neurological Institute and Hospital · CA
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Area of research
Pathology and Forensic Medicine · Radiology, Nuclear Medicine and Imaging
Research interest
Research interests include Multiple Sclerosis Research Studies, Advanced MRI Techniques and Applications, Peripheral Neuropathies and Disorders, and Polyomavirus and related diseases.
h-index
111
citations
52,316
works
1,048
NIH funding
primary concept
email

Recent publications

Tolebrutinib versus Teriflunomide in Relapsing Multiple Sclerosis
New England Journal of Medicine 2025cited by 45position: middledoi
Enabling new insights from old scans by repurposing clinical MRI archives for multiple sclerosis research
Nature Communications 2025cited by 13position: middledoi
Periventricular gradients in axonal and myelin microstructure are present in people with multiple sclerosis having low and high disability
Multiple Sclerosis Journal 2025cited by 1position: middledoi
Safety and efficacy of evobrutinib in relapsing multiple sclerosis (evolutionRMS1 and evolutionRMS2): two multicentre, randomised, double-blind, active-controlled, phase 3 trials
The Lancet Neurology 2024cited by 66position: middledoi
Exploratory clinical efficacy and patient-reported outcomes from NOVA: A randomized controlled study of intravenous natalizumab 6-week dosing versus continued 4-week dosing for relapsing-remitting multiple sclerosis
Multiple Sclerosis and Related Disorders 2023cited by 19position: middledoi
Proportionality-based association metrics in count compositional data
bioRxiv (Cold Spring Harbor Laboratory) 2023cited by 0position: middledoi
How patients with multiple sclerosis acquire disability
Brain 2022cited by 507position: middledoi
Comparison of switching to 6-week dosing of natalizumab versus continuing with 4-week dosing in patients with relapsing-remitting multiple sclerosis (NOVA): a randomised, controlled, open-label, phase 3b trial
The Lancet Neurology 2022cited by 109position: middledoi
Prognostic Value of Serum Neurofilament Light Chain for Disease Activity and Worsening in Patients With Relapsing Multiple Sclerosis: Results From the Phase 3 ASCLEPIOS I and II Trials
Frontiers in Immunology 2022cited by 47position: middledoi
Long-term safety and efficacy of ozanimod in relapsing multiple sclerosis: Up to 5 years of follow-up in the DAYBREAK open-label extension trial
Multiple Sclerosis Journal 2022cited by 47position: middledoi
Long-term efficacy and safety of siponimod in patients with secondary progressive multiple sclerosis: Analysis of EXPAND core and extension data up to >5 years
Multiple Sclerosis Journal 2022cited by 46position: middledoi
A multicentre, open label, single-arm, phase 3b study (CONSONANCE) to assess the effectiveness and safety of ocrelizumab in patients with primary and secondary progressive multiple sclerosis: year-1 interim analysis (P1-1.Virtual)
Neurology 2022cited by 5position: middledoi
Primary Results of NOVA: A Randomized Controlled Study of the Efficacy of 6 Week Dosing of Natalizumab Versus Continued 4-Week Treatment for Multiple Sclerosis
Multiple Sclerosis and Related Disorders 2022cited by 3position: middledoi
A multicenter, open label, single-arm, phase 3b study (CONSONANCE) to assess efficacy of ocrelizumab in patients with primary and secondary progressive multiple sclerosis: year 1 interim analysis of cognition outcomes (P1-1.Virtual)
Neurology 2022cited by 3position: middledoi
Identifying multiple sclerosis subtypes using unsupervised machine learning and MRI data
Nature Communications 2021cited by 255position: middledoi
Secondary Progressive Multiple Sclerosis
Neurology 2021cited by 245position: middledoi
Deep grey matter injury in multiple sclerosis: a NAIMS consensus statement
Brain 2021cited by 76position: middledoi
The gut microbiota in pediatric multiple sclerosis and demyelinating syndromes
Annals of Clinical and Translational Neurology 2021cited by 67position: middledoi
Disrupted cognitive development following pediatric acquired demyelinating syndromes: a longitudinal study
Child Neuropsychology 2021cited by 1position: middledoi
Contribution of Relapse-Independent Progression vs Relapse-Associated Worsening to Overall Confirmed Disability Accumulation in Typical Relapsing Multiple Sclerosis in a Pooled Analysis of 2 Randomized Clinical Trials
JAMA Neurology 2020cited by 599position: middledoi
Long-term follow-up from the ORATORIO trial of ocrelizumab for primary progressive multiple sclerosis: a post-hoc analysis from the ongoing open-label extension of the randomised, placebo-controlled, phase 3 trial
The Lancet Neurology 2020cited by 149position: middledoi
Safety and efficacy of MD1003 (high-dose biotin) in patients with progressive multiple sclerosis (SPI2): a randomised, double-blind, placebo-controlled, phase 3 trial
The Lancet Neurology 2020cited by 104position: middledoi
Efficacy and Safety of 2 Fingolimod Doses vs Glatiramer Acetate for the Treatment of Patients With Relapsing-Remitting Multiple Sclerosis
JAMA Neurology 2020cited by 43position: middledoi
Safety and efficacy of ozanimod versus interferon beta-1a in relapsing multiple sclerosis (SUNBEAM): a multicentre, randomised, minimum 12-month, phase 3 trial
The Lancet Neurology 2019cited by 283position: middledoi
Safety and efficacy of ozanimod versus interferon beta-1a in relapsing multiple sclerosis (RADIANCE): a multicentre, randomised, 24-month, phase 3 trial
The Lancet Neurology 2019cited by 277position: middledoi
Chronic white matter lesion activity predicts clinical progression in primary progressive multiple sclerosis
Brain 2019cited by 213position: lastdoi
Factors associated with health care utilization in pediatric multiple sclerosis
Multiple Sclerosis and Related Disorders 2019cited by 6position: middledoi
Evaluating the efficacy and safety of 6-week extended interval dosing of natalizumab via a prospective, controlled, randomized, open-label, rater-blinded phase 3b study (P3.2-095)
Neurology 2019cited by 3position: middledoi
Loss of intrathalamic tissue integrity in pediatric-onset multiple sclerosis measured with DTI. (P5.2-039)
Neurology 2019cited by 0position: middledoi
Siponimod versus placebo in secondary progressive multiple sclerosis (EXPAND): a double-blind, randomised, phase 3 study
The Lancet 2018cited by 918position: middledoi

Grants

Numerical Solution of Partial Differential Equations: Algorithms, Analysis, and Applications
NSF1719694$300,0002017–2020PIRePORTER
Applications and development of finite element exterior calculus
NSF1418805$387,3872014–2017PIRePORTER
Development and applications of the finite element exterior calculus
NSF1115291$452,8212011–2015PIRePORTER
Finite element exterior calculus and applications
NSF0713568$298,5642007–2011PIRePORTER
Numerical Solution of Partial Differential Equations and Applications
NSF0411388$124,1112004–2007PIRePORTER
IMA New Directions Program: Visitors and Short Courses
NSF0307274$484,2672003–2006PIRePORTER
The Causes and Consequences of Differential Press Coverage of Legislators
NSF0209609$43,9462002–2004PIRePORTER
Numerical Solution of Partial Differential Equations and Applications
NSF0196549$180,0002001–2006PIRePORTER
Numerical Solution of Partial Differential Equations and Applications
NSF0107233$180,0002001–2001PIRePORTER
Numerical Solution of Differential Equations in Mechanics
NSF0296133$45,0002001–2002PIRePORTER
Institute for Mathematics and its Applications
NSF9810289$11,083,7962000–2005PIRePORTER
Numerical Methods in General Relativity
NSF9972835$100,0001999–2000PIRePORTER
Doctoral Dissertation in Political Science: Explaining Patterns of Regulatory Enforcement
NSF9818668$6,4691999–2001PIRePORTER
Numerical Solution of Differential Equations in Mechanics
NSF9870399$200,0001998–2002PIRePORTER
Mathematical Sciences: Numerical Solution of Differential Equations in Mechanics
NSF9500672$124,0001995–1998PIRePORTER
Congress, The Press, and Political Accountability
NSF9422386$100,0321995–1997PIRePORTER
Mathematical Sciences: Numerical Solution of Differential Equations in Mechanics
NSF9205300$255,0001992–1996PIRePORTER
Mathematical Sciences Computing Research Environments
NSF9206985$30,7931992–1994PIRePORTER
Mathematical Sciences: Differential Equations of Mechanics and their Numerical Solution
NSF8913121$163,3701989–1992PIRePORTER
Mathematical Sciences: Differential Equations of Mechanics and Their Numerical Solution
NSF8601489$108,0001986–1989PIRePORTER
Mathematical Sciences: Boundary Element and Finite Element Methods for Partial Differential Equations
NSF8313247$30,0001983–1986PIRePORTER
Mathematical Sciences Research Equipment
NSF8209010$55,0001982–1984PIRePORTER

Frequent collaborators

Amit Bar‐Or · University of California System17 papers (2012–2023)Ludwig Kappos · Department of Biomedicine Basel14 papers (2012–2024)Brenda Banwell · Johns Hopkins University12 papers (2012–2023)Sridar Narayanan · McGill University Health Centre12 papers (2012–2025)Krzysztof Selmaj · Medical University of Lodz10 papers (2012–2022)Eva Havrdová · Université Claude Bernard Lyon 19 papers (2012–2024)Xavier Montalbán · Fundació ACE9 papers (2016–2024)E. Ann Yeh · University of Toronto8 papers (2015–2023)Bruce Cree · California State University, Bakersfield8 papers (2019–2025)Hans‐Peter Hartung · The University of Sydney8 papers (2012–2022)Heinz Wiendl · JDSU (United States)7 papers (2015–2025)Jerry S. Wolinsky · The University of Texas Health Science Center6 papers (2016–2020)Julia O’Mahony · University of Alabama at Birmingham6 papers (2016–2023)Jeffrey A. Cohen · Cleveland Clinic6 papers (2019–2023)D. Louis Collins · Rutgers New Jersey Medical School6 papers (2013–2025)Stephen L. Hauser · University of California, San Francisco5 papers (2018–2022)Gavin Giovannoni · Queen Mary University of London5 papers (2012–2020)Shibeshih Belachew · Allgemeine Gewerbeschule Basel5 papers (2016–2020)Gıancarlo Comı · Ferrari (Italy)5 papers (2016–2022)Declan Chard · Queen Mary University of London4 papers (2021–2025)
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