Area of research
Pulmonary and Respiratory Medicine · Nephrology
Research interest
Research topics from publications: Clinical Significance of IgM and C3 Glomerular Deposition in Primary Focal Segmental Glomerulosclerosis; Complement activation profile of patients with primary focal segmental glomerulosclerosis; Mapping the T cell epitopes of the M-type transmembrane phospholipase A2 receptor in primary membranous nephropathy; Short-chain fatty acids ameliorate experimental anti-glomerular basement membrane disease; The Clinical and Immunologic Features of Patients With Combined Anti-GBM Disease and Castleman Disease. Representative work: BACKGROUND AND OBJECTIVES: Glomerular IgM deposition is commonly shown in primary FSGS and sometimes accompanied by C3 deposition. Clinical presentation and treatment outcomes of these patients are not investigated in detail. DESIGN, SETTING, PARTICIPANTS, &MEASUREMENTS: One hundred six consecutive patients with biopsy-proven primary FSGS from 2004 to 2014 were enrolled retrospectively. Clinical features and treatment outcomes were compared between patients with and without IgM/C3 deposition. RESULTS: Fifty-eight (54.7%) patients presented with IgM glomerular deposition on sclerotic segments. C3 and C1q depositions were shown exclusively in patients with IgM deposition (34.5% versus 0.0%; P3 BACKGROUND: Studies on adriamycin mice model suggest complement system is activated and together with IgM contributes to the glomerular injury of primary focal segmental glomerulosclerosis (FSGS). We recently reported primary FSGS patients with IgM and C3 deposition showed unfavorable therapeutic responses and worse renal outcomes. Here we examined the plasma and urinary complement profile of patients with primary FSGS, aiming to investigate the complement participation in FSGS pathogenesis. METHODS: Seventy patients with biopsy-proven primary FSGS were enrolled. The plasma and urinary levels of C3a, C5a, soluble C5b-9, C4d, C1q, MBL, and Bb were determined by commercial ELISA kits. RESULTS:
Short-chain fatty acids ameliorate experimental anti-glomerular basement membrane disease
Mapping the T cell epitopes of the M-type transmembrane phospholipase A2 receptor in primary membranous nephropathy
Complement activation profile of patients with primary focal segmental glomerulosclerosis
The Clinical and Immunologic Features of Patients With Combined Anti-GBM Disease and Castleman Disease
Clinical Significance of IgM and C3 Glomerular Deposition in Primary Focal Segmental Glomerulosclerosis