Area of research
Molecular Biology · Hepatology
Research interest
Research interests include DNA Repair Mechanisms, Liver physiology and pathology, Pancreatic function and diabetes, and Metabolism and Genetic Disorders.
AAV capsid prioritization in normal and steatotic human livers maintained by machine perfusion
AAV capsid prioritization in normal and steatotic human livers maintained by machine perfusion.
Enhancing the potency of in vivo lentiviral vector mediated gene therapy to hepatocytes.
In vivo assessment of differential toxicity of cancer treatment drugs in Fanconi’s Anemia
Cell networks in the mouse liver during partial hepatectomy.
One Shock, Not One Cure: Electroporation Reveals Disease-Specific Constraints in Hepatocyte Gene Editing Therapy.
Complete correction of murine phenylketonuria by selection-enhanced hepatocyte transplantation.
In vivo selection of hepatocytes.
Long-term combination therapy with metformin and oxymetholone in a Fanconi anemia mouse model.
AAV Capsid Screening for Translational Pig Research Using a Mouse Xenograft Liver Model
A DNA methylation atlas of normal human cell types
A DNA methylation atlas of normal human cell types.
The DNA methylome of human vascular endothelium and its use in liquid biopsies
Rapid in vivo multiplexed editing (RIME) of the adult mouse liver.
Complete correction of murine phenylketonuria by selection-enhanced hepatocyte transplantation
Long-term combination therapy with Metformin and Oxymetholone in a Fanconi Anemia mouse model
Human hepatocyte PNPLA3-148M exacerbates rapid non-alcoholic fatty liver disease development in chimeric mice
Metformin for treatment of cytopenias in children and young adults with Fanconi anemia.
Self-cleaving guide RNAs enable pharmacological selection of precise gene editing events in vivo.
Development of a Beta Cell-Specific Expression Control Element for Recombinant Adeno-Associated Virus.
AAV integration in human hepatocytes.
Liver Injury Increases the Incidence of HCC following AAV Gene Therapy in Mice.
Proliferative polyploid cells give rise to tumors via ploidy reduction.
MYC Promotes Bone Marrow Stem Cell Dysfunction in Fanconi Anemia.
Dynamic Transcriptional and Epigenetic Changes Drive Cellular Plasticity in the Liver.
Generation of functional ciliated cholangiocytes from human pluripotent stem cells.
Therapeutic liver repopulation by transient acetaminophen selection of gene-modified hepatocytes.
The Significance of Polyploid Hepatocytes During Aging Process.
Induced Liver Regeneration Enhances CRISPR/Cas9-Mediated Gene Repair in Tyrosinemia Type 1.
Inhibition of TGFβ1 and TGFβ3 promotes hematopoiesis in Fanconi anemia.