Area of research
Molecular Biology · Physiology
Research interest
Research interests include Nitric Oxide and Endothelin Effects, Cancer-related gene regulation, Wnt/β-catenin signaling in development and cancer, and Antifungal resistance and susceptibility.
Clinical Application of Individualized 3D-Printed Chest Wall Conformal Devicein IMRT for Post-mastectomy Breast Cancer
New ZW4864 Derivatives as Small-Molecule Inhibitors for the β-Catenin/BCL9 Protein-Protein Interaction.
Characterization of Hydrophilic α-Helical Hot Spots on the Protein-Protein Interaction Interfaces for the Design of α-Helix Mimetics.
Fragment hopping protocol for the design of small-molecule protein-protein interaction inhibitors.
Common Structural Features of Hydrophobic α-Helical Hot Spots: Insights for the Design of Novel α-Helix Mimetics.
Direct targeting of β-catenin in the Wnt signaling pathway: Current progress and perspectives.
Preclinical evaluation of [<sup>225</sup>Ac]Ac-DOTA-TATE for treatment of lung neuroendocrine neoplasms.
Discovery of 2-(3-(3-Carbamoylpiperidin-1-yl)phenoxy)acetic Acid Derivatives as Novel Small-Molecule Inhibitors of the β-Catenin/B-Cell Lymphoma 9 Protein–Protein Interaction
Discovery of 2-(3-(3-Carbamoylpiperidin-1-yl)phenoxy)acetic Acid Derivatives as Novel Small-Molecule Inhibitors of the β-Catenin/B-Cell Lymphoma 9 Protein-Protein Interaction.
Discovery of an Orally Bioavailable Small-Molecule Inhibitor for the β-Catenin/B-Cell Lymphoma 9 Protein-Protein Interaction.
Discovery of 1-Benzoyl 4-Phenoxypiperidines as Small-Molecule Inhibitors of the β-Catenin/B-Cell Lymphoma 9 Protein-Protein Interaction.
Inhibition of p53 DNA binding by a small molecule protects mice from radiation toxicity.
Inhibition of β-catenin/B cell lymphoma 9 protein-protein interaction using α-helix-mimicking sulfono-γ-AApeptide inhibitors.
Optimization of Peptidomimetics as Selective Inhibitors for the β-Catenin/T-Cell Factor Protein-Protein Interaction.
Targeting the Side-Chain Convergence of Hydrophobic α-Helical Hot Spots To Design Small-Molecule Mimetics: Key Binding Features for <i>i</i>, <i>i</i> + 3, and <i>i</i> + 7.
A Versatile Method to Determine the Cellular Bioavailability of Small-Molecule Inhibitors
Structure-Based Design of 1,4-Dibenzoylpiperazines as β-Catenin/B-Cell Lymphoma 9 Protein–Protein Interaction Inhibitors
Direct α-heteroarylation of amides (α to nitrogen) and ethers through a benzaldehyde-mediated photoredox reaction
Discovery of Selective Small-Molecule Inhibitors for the β-Catenin/T-Cell Factor Protein–Protein Interaction through the Optimization of the Acyl Hydrazone Moiety
Rational Design of Selective Small-Molecule Inhibitors for β-Catenin/B-Cell Lymphoma 9 Protein–Protein Interactions
Hot spot-based design of small-molecule inhibitors for protein–protein interactions
Targeting the Tcf4 G<sup>13</sup>ANDE<sup>17</sup> Binding Site To Selectively Disrupt β-Catenin/T-Cell Factor Protein–Protein Interactions
High-Throughput Selectivity Assays for Small-Molecule Inhibitors of β-Catenin/T-Cell Factor Protein–Protein Interactions
Partial neuroprotection by nNOS inhibition during profound asphyxia in preterm fetal sheep
ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect
Rational Design of Small-Molecule Inhibitors for β-Catenin/T-Cell Factor Protein–Protein Interactions by Bioisostere Replacement