Area of research
Automotive Engineering · Social Psychology
Research interest
Research topics from publications: Impact of immune cell metabolism on membranous nephropathy and prospective therapy; Activation of the aryl hydrocarbon receptor alleviates Sjögren's syndrome by promoting Bregs differentiation. Representative work: Membranous nephropathy (MN) is a primary glomerular disease commonly causing adult nephrotic syndrome. Characterized by thickened glomerular capillary walls due to immune complex deposition, MN is a complex autoimmune disorder. Its pathogenesis involves immune deposit formation, complement activation, and a heightened risk of renal failure. Central to MN is immune system dysfunction, particularly the dysregulation of B and T cell responses. B cells contribute to renal injury through the production of autoantibodies, particularly IgG targeting the phospholipase A2 receptor (PLA2R) on podocytes, while T cells modulate immune responses that influence disease progression. Metabolic reprogramming