Area of research
Molecular Biology · Pulmonary and Respiratory Medicine
Research interest
Research interests include Single-cell and spatial transcriptomics, CRISPR and Genetic Engineering, Ferroptosis and cancer prognosis, and Genomics and Chromatin Dynamics.
Circulating tumor cell plasticity determines breast cancer therapy resistance via neuregulin 1–HER3 signaling
Functional phenotyping of genomic variants using joint multiomic single-cell DNA–RNA sequencing
PRDX6 contributes to selenocysteine metabolism and ferroptosis resistance
HIPSD&R-seq enables scalable genomic copy number and transcriptome profiling
LRP8‐mediated selenocysteine uptake is a targetable vulnerability in MYCN‐amplified neuroblastoma
Low level of antioxidant capacity biomarkers but not target overexpression predicts vulnerability to ROS-inducing drugs
Low level of antioxidant capacity biomarkers but not target overexpression predicts vulnerability to ROS-inducing drugs
HIPSD&R-seq enables scalable genomic copy number and transcriptome profiling
MYCN mediates cysteine addiction and sensitizes neuroblastoma to ferroptosis
Selenocysteine metabolism is a targetable vulnerability in <i>MYCN</i> -amplified cancers
PAX8 activates metabolic genes via enhancer elements in Renal Cell Carcinoma