Area of research
Cellular and Molecular Neuroscience · Physiology
Research interest
Research interests include Nerve injury and regeneration, Alzheimer's disease research and treatments, Cellular transport and secretion, and Genetic Neurodegenerative Diseases.
BDNF and TRiC-inspired reagent rescue cortical synaptic deficits in a mouse model of Huntington's disease
BDNF/TrkB signaling endosomes in axons coordinate CREB/mTOR activation and protein synthesis in the cell body to induce dendritic growth in cortical neurons
CryoET reveals organelle phenotypes in huntington disease patient iPSC-derived and mouse primary neurons
Novel systemic delivery of a peptide-conjugated antisense oligonucleotide to reduce α-synuclein in a mouse model of Alzheimer's disease
Mitochondria dysfunction in Charcot Marie Tooth 2B Peripheral Sensory Neuropathy
Mitochondria dysfunction in Charcot Marie Tooth 2B Peripheral Sensory Neuropathy
Upregulation of RIN3 induces endosomal dysfunction in Alzheimer’s disease
Aberrant GlyRS-HDAC6 interaction linked to axonal transport deficits in Charcot-Marie-Tooth neuropathy
Dysregulation of Rab5‐mediated endocytic pathways in Alzheimer's disease
Swedish Nerve Growth Factor Mutation (NGF <sup>R100W</sup> ) Defines a Role for TrkA and p75 <sup>NTR</sup> in Nociception
Swedish Nerve Growth Factor Mutation (NGF <sup>R100W</sup> ) Defines a Role for TrkA and p75NTR in Nociception
Synuclein impairs trafficking and signaling of BDNF in a mouse model of Parkinson’s disease
Amyloid precursor protein–mediated endocytic pathway disruption induces axonal dysfunction and neurodegeneration
TRiC subunits enhance BDNF axonal transport and rescue striatal atrophy in Huntington’s disease
Appoptosin-Mediated Caspase Cleavage of Tau Contributes to Progressive Supranuclear Palsy Pathogenesis
Loss of sorting nexin 27 contributes to excitatory synaptic dysfunction by modulating glutamate receptor recycling in Down's syndrome
Defective Axonal Transport of Rab7 GTPase Results in Dysregulated Trophic Signaling
Retromer Binds the FANSHY Sorting Motif in SorLA to Regulate Amyloid Precursor Protein Sorting and Processing
Current advances in using neurotrophic factors to treat neurodegenerative disorders