Area of research
Cellular and Molecular Neuroscience · Behavioral Neuroscience
Research interest
Research interests include Neuroscience and Neuropharmacology Research, Stress Responses and Cortisol, Tryptophan and brain disorders, and Receptor Mechanisms and Signaling.
Contrasting genetic predisposition and diagnosis in psychiatric disorders: A multi-omic single-nucleus analysis of the human OFC
Expanding our understanding of (mal)adapted stress physiology in psychiatric disorders: achieving single-cell characterisation of steroids and neuropeptides
Single-nucleus transcriptomic profiling of human orbitofrontal cortex reveals convergent effects of aging and psychiatric disease
Familial Alzheimer’s Disease Neurons Bearing Mutations in PSEN1 Display Increased Calcium Responses to AMPA as an Early Calcium Dysregulation Phenotype
How spatial omics approaches can be used to map the biological impacts of stress in psychiatric disorders: a perspective, overview and technical guide
Associations of psychiatric disease and ageing with FKBP5 expression converge on superficial layer neurons of the neocortex
Neuronal hyperexcitability in Alzheimer’s disease: what are the drivers behind this aberrant phenotype?
Alterations in Astrocytic Regulation of Excitation and Inhibition by Stress Exposure and in Severe Psychopathology
How stress physically re-shapes the brain: Impact on brain cell shapes, numbers and connections in psychiatric disorders
The Role of Cathepsins in Memory Functions and the Pathophysiology of Psychiatric Disorders
Severe childhood and adulthood stress associates with neocortical layer-specific reductions of mature spines in psychiatric disorders
Understanding the Molecular Mechanisms Underpinning Gene by Environment Interactions in Psychiatric Disorders: The FKBP5 Model
Perinatal administration of phencyclidine alters expression of Lingo-1 signaling pathway proteins in the prefrontal cortex of juvenile and adult rats
Chronic Adolescent CDPPB Treatment Alters Short-Term, but not Long-Term, Glutamatergic Receptor Expression
Preclinical and Clinical Evidence of DNA Methylation Changes in Response to Trauma and Chronic Stress
Effects of common GRM5 genetic variants on cognition, hippocampal volume and mGluR5 protein levels in schizophrenia
Interactions of early-life stress with the genome and epigenome: from prenatal stress to psychiatric disorders
Alterations of ubiquitin related proteins in the pathology and development of schizophrenia: Evidence from human and animal studies
Molecular evidence of synaptic pathology in the CA1 region in schizophrenia
Neurodevelopmental Expression Profile of Dimeric and Monomeric Group 1 mGluRs: Relevance to Schizophrenia Pathogenesis and Treatment
mGluR2/3 agonist LY379268 rescues NMDA and GABAA receptor level deficits induced in a two-hit mouse model of schizophrenia
PM491. The Neurodevelopmental Profile of Group 1 Metabotropic Glutamate Receptors: Implications for Novel Therapeutics
Effects of GRASP variation on memory in psychiatrically healthy individuals and cognitive dysfunction in schizophrenics
Alterations of mGluR5 and its endogenous regulators Norbin, Tamalin and Preso1 in schizophrenia: towards a model of mGluR5 dysregulation
Shifting towards a model of mGluR5 dysregulation in schizophrenia: Consequences for future schizophrenia treatment
Metabotropic glutamate receptor 5, and its trafficking molecules Norbin and Tamalin, are increased in the CA1 hippocampal region of subjects with schizophrenia
Alterations of p75 neurotrophin receptor and Myelin transcription factor 1 in the hippocampus of perinatal phencyclidine treated rats
Homer1/mGluR5 Activity Moderates Vulnerability to Chronic Social Stress
Metabotropic glutamate receptor mGluR2/3 and mGluR5 binding in the anterior cingulate cortex in psychotic and nonpsychotic depression, bipolar disorder and schizophrenia: implications for novel mGluR-based therapeutics
Rethinking metabotropic glutamate receptor 5 pathological findings in psychiatric disorders: implications for the future of novel therapeutics