Area of research
Molecular Biology · Oncology
Research interest
Research interests include RNA modifications and cancer, RNA and protein synthesis mechanisms, RNA Research and Splicing, and Peptidase Inhibition and Analysis.
The putative RNA helicase DDX1 associates with the nuclear RNA exosome and modulates RNA/DNA hybrids (R-loops)
A biallelic variant of the RNA exosome gene, EXOSC4, associated with neurodevelopmental defects impairs RNA exosome function and translation
Maturation of small nucleolar RNAs: from production to function
Ribosomal RNA 2′- <i>O</i> -methylations regulate translation by impacting ribosome dynamics
Phosphorylation regulates arginine-rich RNA-binding protein solubility and oligomerization
Quality control of 40S ribosome head assembly ensures scanning competence
An open interface in the pre-80S ribosome coordinated by ribosome assembly factors Tsr1 and Dim1 enables temporal regulation of Fap7
Subunit joining exposes nascent pre-40S rRNA for processing and quality control
An open interface in the pre-80S ribosome coordinated by ribosome assembly factors Tsr1 and Dim1 enables temporal regulation of Fap7
Structural Heterogeneity in Pre-40S Ribosomes
Hrr25/CK1δ-directed release of Ltv1 from pre-40S ribosomes is necessary for ribosome assembly and cell growth
Heterogeneity in the pre-40S ribosomal subunit reveals two distinct regions of variation at functionally important structural elements