Area of research
Molecular Biology · Genetics · CRISPR base editing
Research interest
Research interests include CRISPR and Genetic Engineering, Fungal and yeast genetics research, RNA and protein synthesis mechanisms, and Genetic Mapping and Diversity in Plants and Animals.
Randomizing the human genome by engineering recombination between repeat elements
Randomizing the human genome by engineering recombination between repeat elements.
A genome-scale single-cell CRISPRi map of trans gene regulation across human pluripotent stem cell lines
The interplay of DNA repair context with target sequence predictably biases Cas9-generated mutations.
A genome-scale single cell CRISPRi map of <i>trans</i> gene regulation across human pluripotent stem cell lines
Engineering structural variants to interrogate genome function.
A genome-scale single cell CRISPRi map of
<i>trans</i>
gene regulation across human pluripotent stem cell lines
Prediction of prime editing insertion efficiencies using sequence features and DNA repair determinants.
Predicting Mutations Generated by Cas9, Base Editing, and Prime Editing in Mammalian Cells.
Genetic variation influencing DNA methylation provides insights into molecular mechanisms regulating genomic function
Live-cell microscopy or fluorescence anisotropy with budded baculoviruses—which way to go with measuring ligand binding to M <sub>4</sub> muscarinic receptors?
ArtSeg-Artifact segmentation and removal in brightfield cell microscopy images without manual pixel-level annotations.
Live-cell microscopy or fluorescence anisotropy with budded baculoviruses-which way to go with measuring ligand binding to M<sub>4</sub> muscarinic receptors?
ArtSeg: Rapid Artifact Segmentation and Removal in Brightfield Cell Microscopy Images
Natural variants suppress mutations in hundreds of essential genes.
Practical segmentation of nuclei in brightfield cell images with neural networks trained on fluorescently labelled samples.
Live-cell microscopy or fluorescence anisotropy with budded baculoviruses - which way to go with measuring ligand binding to M <sub>4</sub> muscarinic receptors?
Live-cell microscopy or fluorescence anisotropy with budded baculoviruses - which way to go with measuring ligand binding to M <sub>4</sub> muscarinic receptors?
Type II and type IV toxin–antitoxin systems show different evolutionary patterns in the global Klebsiella pneumoniae population
JACKS: joint analysis of CRISPR/Cas9 knockout screens.
SLING: a tool to search for linked genes in bacterial datasets
Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes
Characterization of functional methylomes by next-generation capture sequencing identifies novel disease-associated variants
Differential methylation of the TRPA1 promoter in pain sensitivity
Global Analysis of DNA Methylation Variation in Adipose Tissue from Twins Reveals Links to Disease-Associated Variants in Distal Regulatory Elements
Gene expression changes with age in skin, adipose tissue, blood and brain
Mapping cis- and trans-regulatory effects across multiple tissues in twins
Patterns of Cis Regulatory Variation in Diverse Human Populations
Extent, Causes, and Consequences of Small RNA Expression Variation in Human Adipose Tissue