Area of research
Genetics · Molecular Biology
Research interest
Research interests include Glioma Diagnosis and Treatment, Chromatin Remodeling and Cancer, Hedgehog Signaling Pathway Studies, and Epigenetics and DNA Methylation.
Oncogene aberrations drive medulloblastoma progression, not initiation
Advancing CNS tumor diagnostics with expanded DNA methylation-based classification
The clinical and molecular landscape of diffuse hemispheric glioma, H3 G34-mutant
crossNN is an explainable framework for cross-platform DNA methylation-based classification of tumors
The effect of TERT promoter mutation on predicting meningioma outcomes: a multi-institutional cohort analysis
PLAG1 fusions define a third subtype of CNS embryonal tumor with PLAG family gene alteration
European standard clinical practice recommendations for newly diagnosed ependymoma of childhood and adolescence
Advancing CNS tumor diagnostics with expanded DNA methylation-based classification
Investigation of a global mouse methylome atlas reveals subtype-specific copy number alterations in pediatric cancer models
Recurrence patterns in pediatric intracranial ependymal neoplasm: a systematic imaging work-up
The HIT-network for children and adolescents with CNS tumors facilitates improvements of diagnostic assessments, multimodal treatments, individual counselling, and research in Germany, Austria, and Switzerland
Cerebrospinal fluid liquid biopsy guides differential diagnosis of relapsed medulloblastoma versus secondary glioma: A case report of a pediatric patient enrolled on a <i>PDGFRA</i> inhibitor trial
Developing an advanced risk stratification model for pediatric intracranial ependymoma based on the prospective trial E-HIT2000 and subsequent registries
CNSC-81. H3G34-MUTANT DIFFUSE HEMISPHERIC GLIOMAS CONTAIN CELLULAR NICHES OF GABAERGIC INTERNEURON-LIKE CELLS WITH DUAL FREQUENCY AUTONOMOUS RHYTHMIC CALCIUM ACTIVITY
A prognostic neural epigenetic signature in high-grade glioma
GABAergic neuronal lineage development determines clinically actionable targets in diffuse hemispheric glioma, H3G34-mutant
Pituitary neuroendocrine tumors with PIT1/SF1 co-expression show distinct clinicopathological and molecular features
Molecular characteristics and improved survival prediction in a cohort of 2023 ependymomas
EpiDiP/NanoDiP: a versatile unsupervised machine learning edge computing platform for epigenomic tumour diagnostics
Multiomic profiling of medulloblastoma reveals subtype-specific targetable alterations at the proteome and N-glycan level
Integrated analyses reveal two molecularly and clinically distinct subtypes of H3 K27M-mutant diffuse midline gliomas with prognostic significance
Nanopore sequencing from formalin-fixed paraffin-embedded specimens for copy-number profiling and methylation-based CNS tumor classification
Transcriptomic and epigenetic dissection of spinal ependymoma (SP-EPN) identifies clinically relevant subtypes enriched for tumors with and without NF2 mutation
Insights from a multicenter study on adult H3 K27M-mutated glioma: Surgical resection’s limited influence on overall survival, ATRX as molecular prognosticator
Clinically relevant molecular hallmarks of PFA ependymomas display intratumoral heterogeneity and correlate with tumor morphology
Morphology‐based molecular classification of spinal cord ependymomas using deep neural networks
Identification of a putative molecular subtype of adult-type diffuse astrocytoma with recurrent MAPK pathway alterations
Distinct relapse pattern across molecular ependymoma types
Functional screening reveals genetic dependencies and diverging cell cycle control in atypical teratoid rhabdoid tumors
Single-cell transcriptomics link gene expression signatures to clinicopathological features of gonadotroph and lactotroph PitNET