Area of research
Molecular Biology · Cell Biology
Research interest
Research interests include Nuclear Structure and Function, Cellular Mechanics and Interactions, RNA Research and Splicing, and Genomics and Chromatin Dynamics.
Molecular Mechanisms of Human Pancreatic Islet Dysfunction Under Overnutrition Metabolic Stress
Phenotype specific nuclear lamina remodeling in hiPSC derived cardiomyocytes bearing TNNT2 sarcomeric variants
Phenotypic, Genomic, and Transcriptomic Heterogeneity in a Pancreatic Cancer Cell Line
NKX2-2 based nuclei sorting on frozen human archival pancreas enables the enrichment of islet endocrine populations for single-nucleus RNA sequencing
Rotational migration in human pancreatic ductal organoids depends on actin and myosin activity
Cooperative phagocytosis of solid tumours by macrophages triggers durable anti-tumour responses
Nucleus Mechanosensing in Cardiomyocytes
Integrating SNVs and CNAs on a phylogenetic tree from single-cell DNA sequencing data
Differential modulation of cellular phenotype and drug sensitivity by extracellular matrix proteins in primary and metastatic pancreatic cancer cells
Genomic heterogeneity in pancreatic cancer organoids and its stability with culture
CD47-SIRPα Checkpoint Disruption in Metastases Requires Tumor-Targeting Antibody for Molecular and Engineered Macrophage Therapies
Cooperative phagocytosis underlies macrophage immunotherapy of solid tumours and initiates a broad anti-tumour IgG response
Genomic heterogeneity in pancreatic cancer organoids and its stability with culture
Hypertrophic and dilated cardiomyopathy-associatedTNNT2 pathogenic variants induce nucleus remodeling in hiPSC-CM models
Polyploid mitosis and depolyploidization promote chromosomal instability and tumor progression in a Notch-induced tumor model
Gene Signatures of NEUROGENIN3+ Endocrine Progenitor Cells in the Human Pancreas
Live Cell Chromosome Loss Reporter Shows Mechanical Confinement Associates with Chromosome Mis-Segregation
Aggregation‐induced integrated stress response rejuvenates culture‐expanded human mesenchymal stem cells
Nuclear mechanosensing: mechanism and consequences of a nuclear rupture
Heterogeneously Strained Tissue Collagen Resists Collagenase Degradation Where Strains are High
Mitotic progression following DNA damage enables pattern recognition within micronuclei