Area of research
Genetics · Pathology and Forensic Medicine
Research interest
Research interests include Biology, Genetics, Genome, Cancer research, Exome sequencing, and Primate.
A global catalog of whole-genome diversity from 233 primate species
The landscape of tolerated genetic variation in humans and primates
Identification of constrained sequence elements across 239 primate genomes
The Singapore National Precision Medicine Strategy
Analysis of clinically relevant variants from ancestrally diverse Asian genomes
Low frequency variants associated with leukocyte telomere length in the Singapore Chinese population
Variation in predicted COVID‐19 risk among lemurs and lorises
Genetic Studies of Hypertrophic Cardiomyopathy in Singaporeans Identify Variants in <i>TNNI3</i> and <i>TNNT2</i> That Are Common in Chinese Patients
Large-Scale Whole-Genome Sequencing of Three Diverse Asian Populations in Singapore
Integrated paired-end enhancer profiling and whole-genome sequencing reveals recurrent <i>CCNE1</i> and <i>IGF2</i> enhancer hijacking in primary gastric adenocarcinoma
Beyond fitness tracking: The use of consumer-grade wearable data from normal volunteers in cardiovascular and lipidomics research
Whole-Genome and Epigenomic Landscapes of Etiologically Distinct Subtypes of Cholangiocarcinoma
The draft genome of tropical fruit durian (Durio zibethinus)
Loss of tumor suppressor KDM6A amplifies PRC2-regulated transcriptional repression in bladder cancer and can be targeted through inhibition of EZH2
Recognizing the Continuous Nature of Expression Heterogeneity and Clinical Outcomes in Clear Cell Renal Cell Carcinoma
The DNA Structure-Specific Endonuclease MUS81 Mediates DNA Sensor STING-Dependent Host Rejection of Prostate Cancer Cells
JAK-STAT and G-protein-coupled receptor signaling pathways are frequently altered in epitheliotropic intestinal T-cell lymphoma
Genomic landscapes of breast fibroepithelial tumors
Mutational landscapes of tongue carcinoma reveal recurrent mutations in genes of therapeutic and prognostic relevance
Exome sequencing identifies highly recurrent MED12 somatic mutations in breast fibroadenoma
Exome sequencing identifies distinct mutational patterns in liver fluke–related and non-infection-related bile duct cancers
Genome-Wide Mutational Signatures of Aristolochic Acid and Its Application as a Screening Tool