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Wouter van Rheenen

Utrecht University · NL
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Area of research
Neurology · Genetics
Research interest
Research interests include Amyotrophic Lateral Sclerosis Research, Neurogenetic and Muscular Disorders Research, Neurological diseases and metabolism, and Genetic Neurodegenerative Diseases.
h-index
44
citations
11,234
works
109
NIH funding
primary concept
email

Recent publications

An observational study of pleiotropy and penetrance of amyotrophic lateral sclerosis associated with CAG-repeat expansion of ATXN2
European Journal of Human Genetics 2025cited by 6position: middledoi
A <i>VAPB</i> (P56S) mutation in a Dutch patient with familial motor neuron disease: a case report
Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration 2025cited by 0position: middledoi
Mechanism-free repurposing of drugs for C9orf72-related ALS/FTD using large-scale genomic data
Cell Genomics 2024cited by 5position: middledoi
Mechanism-Free Repurposing of Drugs For&amp;nbsp;C9orf72-related ALS/FTD Using Large-Scale Genomic Data
SSRN Electronic Journal 2024cited by 0position: middledoi
Mechanism-Free Repurposing of Drugs For&amp;nbsp;C9orf72-Related ALS/FTD Using Large-Scale Genomic Data
SSRN Electronic Journal 2024cited by 0position: middledoi
Brain expression quantitative trait locus and network analyses reveal downstream effects and putative drivers for brain-related diseases
Nature Genetics 2023cited by 245position: middledoi
Genetic variability in sporadic amyotrophic lateral sclerosis
Brain 2023cited by 80position: middledoi
<i>UNC13A</i>in amyotrophic lateral sclerosis: from genetic association to therapeutic target
Journal of Neurology Neurosurgery & Psychiatry 2023cited by 56position: middledoi
Unexpected frequency of the pathogenic <i>AR</i> CAG repeat expansion in the general population
Brain 2023cited by 28position: middledoi
Assessment of risk of ALS conferred by the GGGGCC hexanucleotide repeat expansion in <i>C9orf72</i> among first-degree relatives of patients with ALS carrying the repeat expansion
Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration 2023cited by 26position: middledoi
Clinical testing panels for ALS: global distribution, consistency, and challenges
Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration 2023cited by 17position: middledoi
Genome-wide study of DNA methylation shows alterations in metabolic, inflammatory, and cholesterol pathways in ALS
Science Translational Medicine 2022cited by 91position: middledoi
Structural variation analysis of 6,500 whole genome sequences in amyotrophic lateral sclerosis
npj Genomic Medicine 2022cited by 43position: middledoi
Functional characterisation of the amyotrophic lateral sclerosis risk locus GPX3/TNIP1
Genome Medicine 2022cited by 38position: middledoi
Telomere length analysis in amyotrophic lateral sclerosis using large-scale whole genome sequence data
Frontiers in Cellular Neuroscience 2022cited by 9position: middledoi
Author Correction: Common and rare variant association analyses in amyotrophic lateral sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology
Nature Genetics 2022cited by 4position: firstdoi
Common and rare variant association analyses in amyotrophic lateral sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology
Nature Genetics 2021cited by 538position: firstdoi
Meta-analysis of genome-wide DNA methylation identifies shared associations across neurodegenerative disorders
Genome biology 2021cited by 104position: middledoi
Association of Variants in the <i>SPTLC1</i> Gene With Juvenile Amyotrophic Lateral Sclerosis
JAMA Neurology 2021cited by 80position: middledoi
Associations between lifestyle and amyotrophic lateral sclerosis stratified by C9orf72 genotype: a longitudinal, population-based, case-control study
The Lancet Neurology 2021cited by 52position: middledoi
<i>SCFD1</i> expression quantitative trait loci in amyotrophic lateral sclerosis are differentially expressed
Brain Communications 2021cited by 29position: middledoi
The Effect of <scp><i>SMN</i></scp> Gene Dosage on <scp>ALS</scp> Risk and Disease Severity
Annals of Neurology 2021cited by 15position: middledoi
Genome-wide association study of intracranial aneurysms identifies 17 risk loci and genetic overlap with clinical risk factors
Nature Genetics 2020cited by 340position: middledoi
Joint sequencing of human and pathogen genomes reveals the genetics of pneumococcal meningitis
Nature Communications 2019cited by 120position: middledoi
The project MinE databrowser: bringing large-scale whole-genome sequencing in ALS to researchers and the public
Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration 2019cited by 92position: middledoi
Prognosis for patients with amyotrophic lateral sclerosis: development and validation of a personalised prediction model
The Lancet Neurology 2018cited by 510position: middledoi
Association of NIPA1 repeat expansions with amyotrophic lateral sclerosis in a large international cohort
Neurobiology of Aging 2018cited by 37position: middledoi
Genome-Wide Analyses Identify KIF5A as a Novel ALS Gene
SSRN Electronic Journal 2018cited by 32position: middledoi
Genetic correlation between amyotrophic lateral sclerosis and schizophrenia
Nature Communications 2017cited by 155position: middledoi
Cross-ethnic meta-analysis identifies association of the GPX3-TNIP1 locus with amyotrophic lateral sclerosis
Nature Communications 2017cited by 121position: middledoi

Grants

No grants ingested yet.

Frequent collaborators

Jan H. Veldink · University Medical Center Utrecht9 papers (2012–2025)Leonard H. van den Berg · University Medical Center Utrecht5 papers (2016–2025)Michael A. van Es · Utrecht University4 papers (2012–2025)Leonard H. van den Berg · Utrecht University4 papers (2012–2023)Philip Van Damme · Universitair Ziekenhuis Leuven3 papers (2012–2025)Ruben P. A. van Eijk · Utrecht University3 papers (2023–2025)R. Jeroen Pasterkamp · Utrecht University3 papers (2012–2023)Rick A. A. van der Spek · Utrecht University2 papers (2019–2021)Sean W. Willemse · Utrecht University2 papers (2023–2025)Albert C. Ludolph · German Center for Neurodegenerative Diseases2 papers (2012–2016)Henk‐Jan Westeneng · Utrecht University2 papers (2021–2023)Koen C. Demaegd · Utrecht University2 papers (2023–2025) · 1 papers (2023–2023)Marka van Blitterswijk · Mayo Clinic in Florida1 papers (2012–2012)Henk Karst · Utrecht University1 papers (2016–2016)Neil A. Shneider · Columbia University Irving Medical Center1 papers (2025–2025)Jelena Medic · University Medical Center Groningen1 papers (2012–2012) · 1 papers (2016–2016)Oliver Harschnitz · Utrecht University1 papers (2016–2016) · 1 papers (2016–2016)
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