Area of research
Cardiology and Cardiovascular Medicine · Molecular Biology
Research interest
Research interests include Cardiac electrophysiology and arrhythmias, Ion channel regulation and function, Cardiac Arrhythmias and Treatments, and Cardiomyopathy and Myosin Studies.
AAV9-mediated KCNH2 suppression-replacement gene therapy in a transgenic rabbit model of type 1 short QT syndrome.
Gene therapy for cardiac arrhythmias.
Sex- and age-dependent differences in detrimental repolarization-prolonging effects of doxorubicin: Evidence of cardiac toxicity beyond heart failure.
Towards a personalized, mechanism-based risk prediction of post-operative atrial fibrillation.
Mechano-electrical feedback in transgenic rabbit models of long QT syndrome Type 2 and short QT syndrome Type 1.
The diagnostic role of pharmacological provocation testing in cardiac electrophysiology: a clinical consensus statement of the European Heart Rhythm Association and the European Association of Percutaneous Cardiovascular Interventions (EAPCI) of the ESC, the ESC Working Group on Cardiovascular Pharmacotherapy, the Association of European Paediatric and Congenital Cardiology (AEPC), the Paediatric & Congenital Electrophysiology Society (PACES), the Heart Rhythm Society (HRS), the Asia Pacific Hea
Sex and sex hormonal regulation of the atrial inward rectifier potassium current (IK1): insights into potential pro-arrhythmic mechanisms.
Beneficial action potential duration-shortening effects, but deleterious negative inotropism of IKs-activator docosahexaenoyl glycine in long QT syndrome type 2.
Rescue of loss-of-function long QT syndrome-associated mutations in K<sub>V</sub>7.1/KCNE1 by the endocannabinoid N-arachidonoyl-L-serine (ARA-S).
Current and future precision therapy approaches in the long QT syndrome.
Therapeutic Efficacy of Mexiletine for Long QT Syndrome Type 2: Evidence From Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes, Transgenic Rabbits, and Patients.
KCNQ1 suppression-replacement gene therapy in transgenic rabbits with type 1 long QT syndrome.
State of Gene Therapy for Monogenic Cardiovascular Diseases
Beneficial normalization of cardiac repolarization by carnitine in transgenic short QT syndrome type 1 rabbit models.
Whole-heart computational modelling provides further mechanistic insights into ST-elevation in Brugada syndrome.
Mechano-electrical interactions and heterogeneities in wild-type and drug-induced long QT syndrome rabbits.
Interactions between KCNQ1 and KCNH2 may modulate the long QT type 1 phenotype.
Commemorating the 1924 Nobel Prize awarded to Willem Einthoven: a century of progress in electrocardiography and arrhythmia research.
25 years of basic and translational science in EP Europace: novel insights into arrhythmia mechanisms and therapeutic strategies.
Gene- and variant-specific efficacy of serum/glucocorticoid-regulated kinase 1 inhibition in long QT syndrome types 1 and 2.
Long-QT mutations in KCNE1 modulate the 17β-estradiol response of Kv7.1/KCNE1.
Simultaneous assessment of mechanical and electrical function in Langendorff-perfused <i>ex-vivo</i> mouse hearts.
Differential Remodeling of Late I<sub>Na</sub> in Paroxysmal and Persistent AF: Another Piece in the Complex Picture of Electrical Remodelling in AF.
Novel Insights Into the Prevalence of <i>TNNI3K</i>-Mediated Dilated Cardiomyopathy and Putative Disease Mechanisms.
Injectable contraceptive Depo-Provera induces erratic beating patterns in patient-specific induced pluripotent stem cell–derived cardiomyocytes with long QT syndrome type 2
Genome-wide association analyses identify new Brugada syndrome risk loci and highlight a new mechanism of sodium channel regulation in disease susceptibility
Genome-wide association analyses identify new Brugada syndrome risk loci and highlight a new mechanism of sodium channel regulation in disease susceptibility.
Deep learning-enabled assessment of cardiac allograft rejection from endomyocardial biopsies
Deep learning-enabled assessment of cardiac allograft rejection from endomyocardial biopsies.
Electromechanical reciprocity and arrhythmogenesis in long-QT syndrome and beyond.