Yilong Fang

Area of research

Immunology · Cellular and Molecular Neuroscience

Research interest

Research topics from publications: CAR-macrophage: A new immunotherapy candidate against solid tumors; The Regulatory Effects of Paeoniflorin and Its Derivative Paeoniflorin-6′-O-Benzene Sulfonate CP-25 on Inflammation and Immune Diseases; Ontogeny of Synovial Macrophages and the Roles of Synovial Macrophages From Different Origins in Arthritis; Synovial Macrophages in Rheumatoid Arthritis: The Past, Present, and Future; Interaction of tumor-associated microglia/macrophages and cancer stem cells in glioma; The role of a key transcription factor PU.1 in autoimmune diseases; The essential role of long non-coding RNA GAS5 in glioma: interaction with microRNAs, chemosensitivity and potential as a biomarker; MicroRNA-10b promotes arthritis development by disrupting CD4+ T cell subtypes; MicroRNA-22 represses glioma development via activation of macrophage-mediated innate and adaptive immune responses. Representative work: Chimeric antigen receptor (CAR)-T cell therapy has been shown to be an effective treatment for hematological tumors, but the treatment of solid tumors still lacks effectiveness. In the tumor microenvironment, macrophages are the innate immune cells with the highest infiltration rate. Tumor-associated macrophages (TAMs) stimulate angiogenesis, increase tumor invasion, and mediate immunosuppression. Because macrophages can infiltrate solid tumor tissue and interact with almost all cellular components in the tumor microenvironment (including tumor cells, immune cells such as T-cells, NK cells, DCs, and other resident non-immune cells), researchers are trying to use macrophages modified with CAR The plant extract “total glucosides of peony” (TGP) constitutes a mixture of glycosides that is isolated from the roots of the well-known traditional Chinese herb Paeonia lactiflora Pall. Paeoniflorin (Pae) is the most abundant component and and the main biologically active ingredient of TGP. Pharmacologically, Pae exhibits powerful anti-inflammatory and immune regulatory effects in some autoimmune diseases including Rheumatoid Arthritis (RA) and Systemic Lupus Erythematosus (SLE). Recently, we isolated an ester derivative of Pea and modified it with an addition of benzene sulfonate to achieve better bioavailability and higher lipid solubility. This review summarizes the pharmacological acti

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