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Kathleen H. Burns

IGM Biosciences (United States) ·
Area of research
Molecular Biology · Immunology
Research interest
Research interests include Immunotherapy and Immune Responses, vaccines and immunoinformatics approaches, Chromosomal and Genetic Variations, and Viral-associated cancers and disorders.
h-index
65
citations
28,300
works
551
NIH funding
primary concept
Biology
email

Recent publications

A breakage–replication/fusion process explains complex rearrangements and segmental DNA amplification
Nature Genetics 2026cited by 4position: middledoi
The Somatic Mosaicism across Human Tissues Network
Nature 2025cited by 39position: middledoi
LINE-1 ORF1p expression occurs in clear cell ovarian carcinoma precursors and is a candidate blood biomarker
npj Precision Oncology 2025cited by 7position: middledoi
Structures, functions and adaptations of the human LINE-1 ORF2 protein
Nature 2023cited by 119position: middledoi
Ultrasensitive Detection of Circulating LINE-1 ORF1p as a Specific Multicancer Biomarker
Cancer Discovery 2023cited by 82position: lastdoi
LINE-1 ORF1p as a candidate biomarker in high grade serous ovarian carcinoma
Scientific Reports 2023cited by 46position: middledoi
Oncogenic Transformation Drives DNA Methylation Loss and Transcriptional Activation at Transposable Element Loci
Cancer Research 2023cited by 27position: middledoi
Author Correction: Comprehensive analysis of chromothripsis in 2,658 human cancers using whole-genome sequencing
Nature Genetics 2023cited by 5position: middledoi
Author Correction: Patterns of somatic structural variation in human cancer genomes
Nature 2023cited by 4position: middledoi
Author Correction: Pan-cancer analysis of whole genomes identifies driver rearrangements promoted by LINE-1 retrotransposition
Nature Genetics 2023cited by 4position: middledoi
Author Correction: Disruption of chromatin folding domains by somatic genomic rearrangements in human cancer
Nature Genetics 2023cited by 1position: middledoi
LINE-1 expression in cancer correlates with p53 mutation, copy number alteration, and S phase checkpoint
Proceedings of the National Academy of Sciences 2022cited by 105position: middledoi
Reverse Transcriptase Inhibition Disrupts Repeat Element Life Cycle in Colorectal Cancer
Cancer Discovery 2022cited by 58position: middledoi
Author Correction: Genomic footprints of activated telomere maintenance mechanisms in cancer
Nature Communications 2022cited by 0position: middledoi
Patterns of somatic structural variation in human cancer genomes
Nature 2020cited by 979position: middledoi
Comprehensive analysis of chromothripsis in 2,658 human cancers using whole-genome sequencing
Nature Genetics 2020cited by 765position: middledoi
Pan-cancer analysis of whole genomes identifies driver rearrangements promoted by LINE-1 retrotransposition
Nature Genetics 2020cited by 472position: middledoi
The HUSH complex is a gatekeeper of type I interferon through epigenetic regulation of LINE-1s
Nature Communications 2020cited by 163position: middledoi
Cell fitness screens reveal a conflict between LINE-1 retrotransposition and DNA replication
Nature Structural & Molecular Biology 2020cited by 141position: lastdoi
Genomic footprints of activated telomere maintenance mechanisms in cancer
Nature Communications 2020cited by 138position: middledoi
Our Conflict with Transposable Elements and Its Implications for Human Disease
Annual Review of Pathology Mechanisms of Disease 2020cited by 136position: firstdoi
High-coverage whole-genome analysis of 1220 cancers reveals hundreds of genes deregulated by rearrangement-mediated cis-regulatory alterations
Nature Communications 2020cited by 75position: middledoi
Publisher Correction: Comprehensive analysis of chromothripsis in 2,658 human cancers using whole-genome sequencing
Nature Genetics 2020cited by 13position: middledoi
Transposable elements in human genetic disease
Nature Reviews Genetics 2019cited by 374position: lastdoi
SQuIRE reveals locus-specific regulation of interspersed repeat expression
Nucleic Acids Research 2019cited by 211position: lastdoi
LINE-1 ORF2p expression is nearly imperceptible in human cancers
Mobile DNA 2019cited by 79position: middledoi
Ten things you should know about transposable elements
Genome biology 2018cited by 1,494position: middledoi
Transposable elements in cancer
Nature reviews. Cancer 2017cited by 581position: firstdoi
The Human Long Interspersed Element-1 Retrotransposon: An Emerging Biomarker of Neoplasia
Clinical Chemistry 2017cited by 157position: lastdoi
Structural variants caused by<i>Alu</i>insertions are associated with risks for many human diseases
Proceedings of the National Academy of Sciences 2017cited by 150position: lastdoi

Grants

Civic Innovation Challenge 3.0
NSF2513329$850,0002025–2027PIRePORTER
Civic Innovation Challenge 2022
NSF2223449$1,018,8482022–2025PIRePORTER
Civic Innovation Challenge
NSF1931690$1,619,2432019–2023PIRePORTER

Frequent collaborators

Jef D. Boeke · NYU Langone Health8 papers (2012–2022)Daniel Ardeljan · Johns Hopkins University5 papers (2017–2020)Martin S. Taylor · Harvard University5 papers (2013–2019)Lindsay M. Payer · Johns Hopkins Medicine4 papers (2017–2020)John LaCava · New York University4 papers (2013–2022)Paolo Mita · New York University4 papers (2013–2022)Jared P. Steranka · Johns Hopkins Medicine4 papers (2015–2020)Nemanja Rodić · University of Florida4 papers (2013–2015)Wan Rou Yang · Johns Hopkins Medicine3 papers (2017–2019)Cheng Ran Lisa Huang · Johns Hopkins University3 papers (2012–2015)David Fenyö · Saint Louis University3 papers (2019–2022) · 2 papers (2022–2023)Xuya Wang · New York University2 papers (2019–2022)Hua Jiang · University of Colorado Denver2 papers (2013–2019)Lixin Dai · Johns Hopkins Medicine2 papers (2013–2016)Wilson McKerrow · NYU Langone Health2 papers (2019–2022)Ralph H. Hruban · Occupational Cancer Research Centre2 papers (2015–2020)Kelly R. Molloy · Rockefeller University2 papers (2013–2019)Michael P Rout · Rockefeller University2 papers (2013–2016)Mikhail Gorbounov · Johns Hopkins Medicine2 papers (2019–2020)