Area of research
Molecular Biology · Cellular and Molecular Neuroscience
Research interest
Research interests include Receptor Mechanisms and Signaling, Neuropeptides and Animal Physiology, Diabetes Treatment and Management, and Academic Writing and Publishing.
Conformational Dynamics of Amylin Receptors Revealed by Hydrogen-Deuterium Exchange Mass Spectrometry.
Altered Intracellular Trafficking as a Mechanism for Prolonged Duration of G Protein-Coupled Receptor Activation.
In vivo functional profiling and structural characterization of the human <i>GLP1R</i> A316T variant.
De novo design of miniproteins targeting GPCRs
A versatile antibody capture system drives specific in vivo delivery of mRNA-loaded lipid nanoparticles.
Structural and dynamic features of cagrilintide binding to calcitonin and amylin receptors.
Prolonged signaling of backbone-modified glucagon-like peptide-<b>1</b> analogues with diverse receptor trafficking.
Cryoelectron microscopy as a tool for illuminating activation mechanisms of human class A orphan G protein-coupled receptors.
Unique Biased Agonism Profile of βCGRP on CGRP Family Receptors.
Structural basis of modified ligand selectivity from N-terminal PAC1R alternative splicing.
Cholesterol residence time drives regulation of the G protein-coupled cholecystokinin receptor.
Native adenosine A<sub>2A</sub> receptor solubilisation by a library of amphipathic copolymers.
Structural insight into selectivity of amylin and calcitonin receptor agonists.
Lipid-Dependent Activation of the Orphan G Protein-Coupled Receptor, GPR3.
Opportunities and challenges for the development of M<sub>1</sub> muscarinic receptor positive allosteric modulators in the treatment for neurocognitive deficits.
Development of a Novel Assay for Direct Assessment of Selective Amylin Receptor Activation Reveals Novel Differences in Behavior of Selective and Nonselective Peptide Agonists.
Cryo-EM Structure of the Human Amylin 1 Receptor in Complex with CGRP and Gs Protein.
Porous Silicon Microparticles Enable Sustained Release of GLP‐1R Agonist Peptides for the Treatment of Type 2 Diabetes
Impact of secretin receptor homo-dimerization on natural ligand binding.
Prolonged signaling of backbone-modified glucagon-like peptide-1 analogues with diverse receptor trafficking
New Insights into the Structure and Function of Class B1 GPCRs.
Structural basis of efficacy-driven ligand selectivity at GPCRs.
Xanomeline displays concomitant orthosteric and allosteric binding modes at the M<sub>4</sub> mAChR.
Author Correction: Structural basis of efficacy-driven ligand selectivity at GPCRs.
A structural basis for amylin receptor phenotype.
Dynamics of GLP-1R peptide agonist engagement are correlated with kinetics of G protein activation.
Structural and functional diversity among agonist-bound states of the GLP-1 receptor.
Membranes under the Magnetic Lens: A Dive into the Diverse World of Membrane Protein Structures Using Cryo-EM.
Understanding VPAC receptor family peptide binding and selectivity.
M<sub>1</sub> muscarinic receptor activation reduces the molecular pathology and slows the progression of prion-mediated neurodegenerative disease.