Area of research
Nephrology · Molecular Biology
Research interest
Research interests include Renal Diseases and Glomerulopathies, Chronic Kidney Disease and Diabetes, Renal and related cancers, and Genetic and Kidney Cyst Diseases.
Injury-induced paracrine effects on the podocyte's transcriptome.
A single cell atlas of mouse podocytes upon injury identifies kidney zone-dependent responses
SPATIALLY PATTERNED PODOCYTE STATE TRANSITIONS COORDINATE AGING OF THE GLOMERULUS
Podocyte injury at young age causes premature senescence and worsens glomerular aging.
Podocytes from hypertensive and obese mice acquire an inflammatory, senescent, and aged phenotype.
Loss of epigenetic information as a cause of mammalian aging
Inhibiting NLRP3 signaling in aging podocytes improves their life- and health-span
Inhibiting NLRP3 signaling in aging podocytes improves their life- and health-span.
Podocyte injury at young age causes premature senescence and worsens glomerular aging
Podocyte Senescence and Aging.
Upregulated PD-1 signaling antagonizes glomerular health in aged kidneys and disease
Upregulated PD-1 signaling antagonizes glomerular health in aged kidneys and disease.
Podocyte Aging: Why and How Getting Old Matters.
The Atypical Cyclin-Dependent Kinase 5 (Cdk5) Guards Podocytes from Apoptosis in Glomerular Disease While Being Dispensable for Podocyte Development.
Feature-rich covalent stains for super-resolution and cleared tissue fluorescence microscopy.
Global transcriptomic changes occur in aged mouse podocytes.
Parietal epithelial cell differentiation to a podocyte fate in the aged mouse kidney.
Nanoparticles exhibit greater accumulation in kidney glomeruli during experimental glomerular kidney disease.
CD44 impacts glomerular parietal epithelial cell changes in the aged mouse kidney.
Dual lineage tracing shows that glomerular parietal epithelial cells can transdifferentiate toward the adult podocyte fate.
Differential expression of parietal epithelial cell and podocyte extracellular matrix proteins in focal segmental glomerulosclerosis and diabetic nephropathy
Differential expression of parietal epithelial cell and podocyte extracellular matrix proteins in focal segmental glomerulosclerosis and diabetic nephropathy.
Optimized nonviral gene delivery for primary urinary renal progenitor cells to enhance cell migration.
High-Throughput Screening Enhances Kidney Organoid Differentiation from Human Pluripotent Stem Cells and Enables Automated Multidimensional Phenotyping
Glomerular disease augments kidney accumulation of synthetic anionic polymers
The mitochondrial-targeted peptide, SS-31, improves glomerular architecture in mice of advanced age
Retinoic acid improves nephrotoxic serum–induced glomerulonephritis through activation of podocyte retinoic acid receptor α
WT1 Is Necessary for the Proliferation and Migration of Cells of Renin Lineage Following Kidney Podocyte Depletion
Urinary Podocyte Loss Is Increased in Patients with Fabry Disease and Correlates with Clinical Severity of Fabry Nephropathy