Area of research
Physiology · Pharmacology
Research interest
Research interests include Genetically modified mouse, Transthyretin, Neurodegeneration, Microglia, Alzheimer's disease, and Neuroscience.
Can brain network connectivity facilitate the clinical development of disease-modifying anti-Alzheimer drugs?
A p75 neurotrophin receptor‐sparing nerve growth factor protects retinal ganglion cells from neurodegeneration by targeting microglia
Plasma Amyloid-β dynamics in late-life major depression: a longitudinal study
The β-Secretase BACE1 in Alzheimer’s Disease
A Path Toward Precision Medicine for Neuroinflammatory Mechanisms in Alzheimer's Disease
Amyloid deposition in a mouse model humanized at the transthyretin and retinol-binding protein 4 loci
CSP-1103 (CHF5074) stabilizes human transthyretin in healthy human subjects
Tau-directed approaches for the treatment of Alzheimer’s disease: focus on leuco-methylthioninium
CHF5074 (CSP‐1103) stabilizes human transthyretin in mice humanized at the transthyretin and retinol‐binding protein loci
CHF5074 and LY450139 sub-acute treatments differently affect cortical extracellular glutamate levels in pre-plaque Tg2576 mice
Multi-target action of the novel anti-Alzheimer compound CHF5074: in vivo study of long term treatment in Tg2576 mice
Structural evidence for native state stabilization of a conformationally labile amyloidogenic transthyretin variant by fibrillogenesis inhibitors
Receptor for Advanced Glycation End Products Contributes to Postnatal Pulmonary Development and Adult Lung Maintenance Program in Mice
<scp>CHF</scp>5074 restores visual memory ability and pre‐synaptic cortical acetylcholine release in pre‐plaque Tg2576 mice
P2‐115: <i>In vivo</i> and <i>in vitro</i> study on microglia activation of CHF5074, a nonsteroidal anti‐inflammatory derivative with gamma‐secretase modulatory activity