Area of research
Molecular Biology · Ecology
Research interest
Research interests include CRISPR and Genetic Engineering, RNA and protein synthesis mechanisms, Bacteriophages and microbial interactions, and Protein Structure and Dynamics.
TIGR-Tas: A family of modular RNA-guided DNA-targeting systems in prokaryotes and their viruses
Evolution-guided protein design of IscB for persistent epigenome editing in vivo
Human paraneoplastic antigen Ma2 (PNMA2) forms icosahedral capsids that can be engineered for mRNA delivery
Structural insights into the diversity and DNA cleavage mechanism of Fanzor
Internal initiation of reverse transcription in a Penelope-like retrotransposon
Fanzor is a eukaryotic programmable RNA-guided endonuclease
Cell type-specific delivery by modular envelope design
The Transposon-Encoded Protein TnpB Processes Its Own mRNA into ωRNA for Guided Nuclease Activity
Modularity and diversity of target selectors in Tn7 transposons
RNA-activated protein cleavage with a CRISPR-associated endopeptidase
Epistasis at the SARS-CoV-2 Receptor-Binding Domain Interface and the Propitiously Boring Implications for Vaccine Escape
Structure of the OMEGA nickase IsrB in complex with ωRNA and target DNA
Ongoing global and regional adaptive evolution of SARS-CoV-2
Mitochondria-rough-ER contacts in the liver regulate systemic lipid homeostasis
Dual modes of CRISPR-associated transposon homing
Detection of SARS-CoV-2 with SHERLOCK One-Pot Testing
Genomic determinants of pathogenicity in SARS-CoV-2 and other human coronaviruses
CRISPR–Cas in mobile genetic elements: counter-defence and beyond
Translational coupling via termination-reinitiation in archaea and bacteria
Protein flexibility in the light of structural alphabets