Area of research
Molecular Biology · Orthopedics and Sports Medicine
Research interest
Research interests include Bone Metabolism and Diseases, Bone health and osteoporosis research, TGF-β signaling in diseases, and Osteoarthritis Treatment and Mechanisms.
Preclinical perspectives on disorders of the temporomandibular joint: Tracing the past, navigating the present, and shaping the future
Aging impairs the osteocytic regulation of collagen integrity and bone quality
High-fat and high-carbohydrate diets increase bone fragility through TGF-β–dependent control of osteocyte function
Molecular and Cellular Crosstalk between Bone and Brain: Accessing Bidirectional Neural and Musculoskeletal Signaling during Aging and Disease
Osteoarthritis Pathophysiology
Disrupted osteocyte connectivity and pericellular fluid flow in bone with aging and defective TGF-β signaling
TGFβ Regulation of Perilacunar/Canalicular Remodeling Is Sexually Dimorphic
Quantitative and qualitative bone imaging: A review of synchrotron radiation microtomography analysis in bone research
Osteocyte dysfunction promotes osteoarthritis through MMP13-dependent suppression of subchondral bone homeostasis
Investigating Osteocytic Perilacunar/Canalicular Remodeling
Chronic kidney disease and aging differentially diminish bone material and microarchitecture in C57Bl/6 mice
Fatigue as the missing link between bone fragility and fracture
Contributions of Material Properties and Structure to Increased Bone Fragility for a Given Bone Mass in the UCD-T2DM Rat Model of Type 2 Diabetes
Osteocyte-Intrinsic TGF-β Signaling Regulates Bone Quality through Perilacunar/Canalicular Remodeling
Glucocorticoid suppression of osteocyte perilacunar remodeling is associated with subchondral bone degeneration in osteonecrosis
Bone marrow lesions in osteoarthritis: What lies beneath
Mechanobiology of TGFβ signaling in the skeleton
Discrete spatial organization of TGFβ receptors couples receptor multimerization and signaling to cellular tension
Author response: Discrete spatial organization of TGFβ receptors couples receptor multimerization and signaling to cellular tension
How Tough Is Brittle Bone? Investigating Osteogenesis Imperfecta in Mouse Bone
Biological Regulation of Bone Quality
Smad3 binds scleraxis and mohawk and regulates tendon matrix organization
Accumulation of Exogenous Activated TGF-β in the Superficial Zone of Articular Cartilage
Load Regulates Bone Formation and Sclerostin Expression through a TGFβ-Dependent Mechanism
Regulation of postnatal bone homeostasis by TGFβ
Ligand-Independent and Tissue-Selective Androgen Receptor Inhibition by Pyrvinium
Evolution of a developmental mechanism: Species-specific regulation of the cell cycle and the timing of events during craniofacial osteogenesis
Matrix metalloproteinase–13 is required for osteocytic perilacunar remodeling and maintains bone fracture resistance
ECM stiffness primes the TGFβ pathway to promote chondrocyte differentiation
Chondrocyte‐intrinsic Smad3 represses Runx2‐inducible matrix metalloproteinase 13 expression to maintain articular cartilage and prevent osteoarthritis